DCPS — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1154603	1.00	17/20
SCHEMBL2165471	1.00	17/20
SCHEMBL2164670	0.85	17/20
SCHEMBL1154903	0.83	17/20
Hydrochloric Acid (SCHEMBL2164539)	0.81	17/20
SCHEMBL2164643	0.81	17/20
SCHEMBL2165315	0.80	17/20
SCHEMBL2164948	0.80	17/20
SCHEMBL2165491	0.80	17/20
SCHEMBL2165553	0.80	17/20
SCHEMBL2164555	0.78	17/20
SCHEMBL2164756	0.78	17/20
SCHEMBL2164432	0.77	17/20
SCHEMBL2164650	0.76	17/20
SCHEMBL2165588	0.74	17/20
SCHEMBL1155228	0.74	17/20
SCHEMBL1155318	0.74	17/20
Hydrochloric Acid (SCHEMBL1154677)	0.72	17/20
SCHEMBL2165373	0.72	17/20
SCHEMBL2165318	0.72	17/20

Clinical trials — most relevant to DCPS by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
DPYD Pharmacogenomics and Fluoropyrimidine (FP) Dose-Adjustment	PHASE4	RECRUITING
Acelarin First Line Randomised Pancreatic Study	PHASE2/PHASE3	SUSPENDED
Alendronate Versus Denosumab in Kidney Transplant Patients	PHASE2/PHASE3	COMPLETED
Study of Intrathecal Idursulfase-IT Administered in Conjunction With Elaprase® in Pediatric Patients With Hunter Syndrome and Early Cognitive Impairment	PHASE2/PHASE3	COMPLETED
A Study of KRN23 in Pediatric Patients With X-linked Hypophosphatemic Rickets/Osteomalacia	PHASE3	COMPLETED
Safety and Efficacy of BMS-986504 in Unresectable Malignant Peripheral Nerve Sheath Tumor	PHASE1/PHASE2	NOT_YET_RECRUITING
Clinical Study of EBV-LMP1 Targeted DNAzyme to Treat Nasopharyngeal Carcinoma	PHASE1/PHASE2	COMPLETED
NEO100 and High-Grade Meningioma	PHASE2	RECRUITING
A Study of the Tolerance, Safety, and Pharmacokinetics of GNR-055 in Healthy Volunteers	PHASE1	COMPLETED
Novel Peptide Vaccination for Patients With Advanced Bladder Cancer	PHASE1	COMPLETED
Biomarker for Hypophosphatasia Disease (BioHypophos)	nan	WITHDRAWN
RCDP Natural History Study	nan	UNKNOWN
Unraveling Genetics of HypoPhosPhatasia (HPP Genetics)	nan	COMPLETED
PCD New Gene Discovery	nan	COMPLETED
Genetic Studies of Lysosomal Storage Disorders	nan	ENROLLING_BY_INVITATION
Biomarker for Mucolipidosis Disorder Type I, II, III, IV (BioML)	nan	WITHDRAWN
A Study Providing Genetic Testing to Find Those Who May Have Primary Ciliary Dyskinesia for Potential Clinical Trials	nan	ACTIVE_NOT_RECRUITING
Phenotype/Genotype Correlations in Neuromuscular Disorders	nan	COMPLETED
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH)	nan	COMPLETED
Evaluation of Possible Genes in Periodontal Diseases by Genetic Methods	nan	UNKNOWN
Natural History Study of Mitochondrial Myopathy	nan	RECRUITING
Erythropoietic Protoporphyrias: Studies of the Natural History, Genotype-Phenotype Correlations, and Psychosocial Impact	nan	COMPLETED
Developing a Management Approach for Patients With Late-Onset Pompe Disease	nan	ACTIVE_NOT_RECRUITING
Genetic Analysis of Inherited Urologic Malignant Disorders: Collection of Samples	nan	COMPLETED
The Congenital Dyserythropoietic Anemia Registry (CDAR)	nan	RECRUITING
Circadian Rhythms and Sleep in Familial DSPS and ASPS	nan	COMPLETED
Natural History Study of Patients With Hypophosphatasia (HPP)	nan	RECRUITING
Institution of an Italian Multicenter Database of Patients Affected by Diseases of Phosphate Metabolism	nan	NOT_YET_RECRUITING
Using Next-generation Sequencing in the Diagnosis of Epilepsy and/or Intellectual Disability in a Pediatric Cohorte	nan	COMPLETED
Chest Wall Deformities in Children - Epidemiological Data	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a DCPS binder may also engage these)

Protein	Name	Similarity
Q8MJJ7	—	1.000	Q8MJJ7 →
Q8MIZ3	—	1.000	Q8MIZ3 →
Q8K4F7	—	1.000	Q8K4F7 →
Q9DAR7	—	1.000	Q9DAR7 →
D3K0N9	—	0.990	D3K0N9 →
Q9P7C9	—	0.989	Q9P7C9 →
G5EFS4	—	0.987	G5EFS4 →
Q8WYJ6	—	0.982	Q8WYJ6 →
Q8WTJ4	—	0.980	Q8WTJ4 →
Q7Q727	—	0.980	Q7Q727 →
Q9W3C1	—	0.980	Q9W3C1 →
Q5JPH6	—	0.979	Q5JPH6 →
O02655	—	0.979	O02655 →
Q9VN19	—	0.979	Q9VN19 →
Q28DX0	—	0.979	Q28DX0 →
Q06151	—	0.979	Q06151 →
P93028	—	0.979	P93028 →
Q84WU9	—	0.979	Q84WU9 →
Q9W3R7	—	0.979	Q9W3R7 →
TBCD	Tubulin-specific chaperone D	0.979	landscape →
Q9VM60	—	0.979	Q9VM60 →
Q24087	—	0.978	Q24087 →
A7KAL8	—	0.978	A7KAL8 →
ALKBH2	DNA oxidative demethylase ALKBH2	0.978	landscape →
Q9VR56	—	0.978	Q9VR56 →
Q9VTE9	—	0.978	Q9VTE9 →
A8IW34	—	0.978	A8IW34 →
P47758	—	0.978	P47758 →
Q9CQN1	—	0.978	Q9CQN1 →
MLYCD	Malonyl-CoA decarboxylase, mitochondrial	0.978	landscape →