Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Betamethasone Acetate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 9/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 7/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 7/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | CNR1 | P21554 | 1/20 | 1.00 |
| ▸ | TBXA2R | P21731 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.79 |
| ▸ | TSHR | P16473 | 2/20 | 0.79 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.79 |
| ▸ | PGR | P06401 | 2/20 | 0.79 |
| ▸ | AR | P10275 | 2/20 | 0.79 |
| ▸ | MEN1 | O00255 | 1/20 | 0.79 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.79 |
| ▸ | APEX1 | P27695 | 1/20 | 0.79 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.79 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.79 |
| ▸ | IKBKB | O14920 | 1/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Betamethasone Acetate SCHEMBL13044485 | 1.00 | NR3C1 (1.00) | NR3C1HIF1ACYP3A4LMNACYP2C9 | |
| Betamethasone Acetate SCHEMBL13840949 | 1.00 | NR3C1 (1.00) | NR3C1HIF1ACYP3A4LMNACYP2C9 | |
| Betamethasone Acetate SCHEMBL5917208 | 1.00 | NR3C1 (1.00) | NR3C1HIF1ACYP3A4LMNACYP2C9 | |
| Betamethasone Acetate SCHEMBL7592 | 1.00 | NR3C1 (1.00) | NR3C1HIF1ACYP3A4LMNACYP2C9 | |
| Betamethasone Acetate SCHEMBL5917205 | 1.00 | NR3C1 (1.00) | NR3C1HIF1ACYP3A4LMNACYP2C9 | |
| Betamethasone Acetate SCHEMBL1116231 | 1.00 | NR3C1 (1.00) | NR3C1HIF1ACYP3A4LMNACYP2C9 | |
| Betamethasone Acetate SCHEMBL10412637 | 1.00 | NR3C1 (1.00) | NR3C1HIF1ACYP3A4LMNACYP2C9 | |
| Dexamethasone Acetate SCHEMBL136861 | 1.00 | NR3C1 (1.00) | NR3C1HIF1ACYP3A4LMNACYP2C9 | |
| Betamethasone Acetate SCHEMBL3625942 | 1.00 | NR3C1 (1.00) | NR3C1HIF1ACYP3A4LMNACYP2C9 | |
| Betamethasone Acetate SCHEMBL7546 | 1.00 | NR3C1 (1.00) | NR3C1HIF1ACYP3A4LMNACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8092822-B2 | Coatings including dexamethasone derivatives and analogs and olimus drugs | ABBOTT CARDIOVASCULAR SYSTEMS INC. (US) | 2012-01-10 | — | — | US | disclosed |
| US-8092822-B2 | Coatings including dexamethasone derivatives and analogs and olimus drugs | ABBOTT CARDIOVASCULAR SYSTEMS INC. (US) | 2012-01-10 | — | — | US | disclosed |
| US-20100082095-A1 | Coatings Including Dexamethasone Derivatives And Analogs And Olimus Drugs | ABBOTT CARDIOVASCULAR SYSTEMS INC. (US) | 2010-04-01 | — | — | US | disclosed |
| US-20100082095-A1 | Coatings Including Dexamethasone Derivatives And Analogs And Olimus Drugs | ABBOTT CARDIOVASCULAR SYSTEMS INC. (US) | 2010-04-01 | — | — | US | disclosed |
| WO-2010036537-A2 | COATINGS INCLUDING DEXAMETHASONE DERIVATIVES AND ANALOGS AND OLIMUS DRUGS | ABBOTT CARDIOVASCULAR SYSTEMS INC. (US) | 2010-04-01 | — | — | WO | disclosed |