NR3C1

Glucocorticoid receptor · P04150 · NR3C1 on Sugi Atlas →

259,837 patent compounds predicted against NR3C1, 173,950 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Betamethasone Benzoate (SCHEMBL49469)	0.77	18/20
SCHEMBL7812	0.73	18/20
Cortivazol (SCHEMBL4875)	0.47	18/20
SCHEMBL7547	0.83	17/20
SCHEMBL4149	0.76	15/20
Mazipredone (SCHEMBL25720)	0.75	15/20
Fluticasone Propionate (SCHEMBL4068)	1.00	14/20
Fluticasone (SCHEMBL4069)	1.00	14/20
Fluticasone Propionate (SCHEMBL4283)	1.00	14/20
Loteprednol Etabonate (SCHEMBL23907)	1.00	14/20
SCHEMBL4284	0.83	14/20
SCHEMBL9468	0.76	14/20
Dexbudesonide (SCHEMBL4095)	1.00	13/20
Budesonide (SCHEMBL4096)	1.00	13/20
Betamethasone Valerate (SCHEMBL7270)	1.00	13/20
Budesonide (SCHEMBL19635)	1.00	13/20
Cloticasone Propionate (SCHEMBL42706)	0.87	13/20
Prednisolone Phosphoric Acid (SCHEMBL7512)	0.76	13/20
Prednisolone Phosphoric Acid (SCHEMBL23563)	0.75	13/20
SCHEMBL3826	0.74	13/20

Clinical trials — most relevant to NR3C1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Tumor Gene Expression in Women With Ovarian Cancer	PHASE4	COMPLETED
Effects of the Addition of Metyrapone to Antidepressant Therapy in Depression With Dexamethasone Suppression Test Non-suppression.	PHASE4	UNKNOWN
Rapid Effects of Hydrocortisone on Glucose-induced Insulin Secretion in Healthy Humans	PHASE4	COMPLETED
Counteracting Deleterious Metabolic Glucocorticoid Effects With Metformin	PHASE4	COMPLETED
Effect of Symbicort ® on GR in Sputum in COPD	PHASE4	COMPLETED
The Use of Inhaled Corticosteroids in the Treatment of Asthma is Children in the Emergency Room	PHASE2/PHASE3	COMPLETED
A Comparative Study of Glucocorticoids Efficacy in Acute Respiratory Distress Syndrome	PHASE2/PHASE3	RECRUITING
Effects of Advair® in Outpatients With Chronic Obstructive Pulmonary Disease (COPD) Acute Exacerbation	PHASE3	COMPLETED
RESET-medication Glucocorticoid Receptor (GR) Blockade As Disease Modifying Treatment for Depression with Childhood Trauma	PHASE2	COMPLETED
Novel Therapeutics in Posttraumatic Stress Disorder (PTSD): A Randomized Clinical Trial of Mifepristone	PHASE2	COMPLETED
Effects of a Multiple Sclerosis Relapse Therapy on Offspring Neurocognitive Development and Behaviour	nan	UNKNOWN
Multi-level Molecular Profiling of High Acute Stress: a Clinical Study	nan	UNKNOWN
Syndromes With Neonatal Salt Loss: Not Only Congenital Adrenal Hyperplasia Due to 21-hydroxylase Deficiency (21OH-ISC)	nan	RECRUITING
Stress and Treatment Response in Puerto Rican Children With Asthma	nan	COMPLETED
Safety and Efficacy of DSM 32444 Postbiotic in the Treatment of Acute Rhinosinusitis	nan	COMPLETED
Effect of Surgical or Conservative Approach in Patients With Adrenal Incidentalomas	nan	UNKNOWN
Personalised Pharmacological Approach to the Tapering of Corticosteroid Doses in Systemic Lupus Patients Treated With Prednisone	nan	COMPLETED
Global Mental Health of Urban Mothers	nan	UNKNOWN
Pattern of Gene Expression in Adipose Tissue From Patients With Cushing Syndrome	nan	COMPLETED
Steroid Treatment of Idiopathic Nephrotic Syndrome	nan	COMPLETED
Studying Dexamethasone and Prednisone Sensitivity in Samples From Younger Patients With High-Risk B-Cell Precursor Acute Lymphoblastic Leukemia	nan	COMPLETED
Evaluation of High Dose Prednisolone Pharmacokinetics in the Acute and Chronic Setting	nan	RECRUITING
RESIST: Understanding the Role of Depression in Heart Disease	nan	COMPLETED
PATHophysiology of OSteoporosis: Role of Hidden Cortisol Excess and Its Predictors in Bone Fragility	nan	UNKNOWN
The Role of Timing of Dexamethasone Administration on Pain Scores and Quality of Recovery in Cesarean Section.	nan	COMPLETED
Family Resilience Initiative Research Program	nan	UNKNOWN
Dexamethasone and Pregnancy: Maternal Effects	nan	RECRUITING
Difference in GC-induced Adrenal Insufficiency in RA Related to Polymorphisms in the Glucocorticoid Receptor Gene	nan	UNKNOWN
Examining Genetic Differences Among People With 21-Hydroxylase Deficiency	nan	COMPLETED
Cortisol Circadian Rhythm in Patients With RA	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a NR3C1 binder may also engage these)

Protein	Name	Similarity
Q5R9P5	—	1.000	Q5R9P5 →
Q8AYI2	—	1.000	Q8AYI2 →
P06536	—	1.000	P06536 →
P06537	—	1.000	P06537 →
Q91573	—	1.000	Q91573 →
P49844	—	1.000	P49844 →
Q9N1U3	—	1.000	Q9N1U3 →
P79269	—	1.000	P79269 →
P49699	—	0.998	P49699 →
Q6XLJ0	—	0.998	Q6XLJ0 →
Q6YXZ4	—	0.997	Q6YXZ4 →
Q3YC04	—	0.997	Q3YC04 →
P59667	—	0.997	P59667 →
Q8VII8	—	0.997	Q8VII8 →
Q4JM28	—	0.997	Q4JM28 →
Q29131	—	0.997	Q29131 →
O97952	—	0.997	O97952 →
Q95QY7	—	0.997	Q95QY7 →
TFDP2	Transcription factor Dp-2	0.996	landscape →
O13186	—	0.996	O13186 →
O97776	—	0.996	O97776 →
Q95267	—	0.996	Q95267 →
P79686	—	0.996	P79686 →
P22199	—	0.996	P22199 →
O73673	—	0.996	O73673 →
P49115	—	0.996	P49115 →
O01409	—	0.996	O01409 →
P79742	—	0.995	P79742 →
Q1KKW8	—	0.995	Q1KKW8 →
Q9H329	—	0.995	Q9H329 →