Sugi Predict

Sugi Predict / Compounds / SCHEMBL10042947

SCHEMBL10042947

SCHEMBL10042947

COc1ccc(C2(O)c3ccc(C)c(C)c3OCC2c2ccc(O)cc2)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALOX15 P16050 3/20 0.38
▸ ALOX12 P18054 3/20 0.38
▸ NPC1 O15118 1/20 0.37
▸ GAA P10253 1/20 0.37
▸ ATM Q13315 1/20 0.37
▸ NPSR1 Q6W5P4 1/20 0.37
▸ PDE4D Q08499 2/20 0.33
▸ CHRNA1 P02708 1/20 0.33
▸ CHRNG P07510 1/20 0.33
▸ CHRNB1 P11230 1/20 0.33
▸ CHRNB2 P17787 1/20 0.33
▸ CHRNB4 P30926 1/20 0.33
▸ CHRNA3 P32297 1/20 0.33
▸ CHRNA4 P43681 1/20 0.33
▸ CHRND Q07001 1/20 0.33
▸ LTA4H P09960 1/20 0.33
▸ ESR2 Q92731 1/20 0.33
▸ MAPT P10636 1/20 0.32
▸ KMT2A Q03164 1/20 0.32
▸ KCNH2 Q12809 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10042943 0.96 GAA (0.39) ALOX15ALOX12NPC1GAAATM
SCHEMBL13673328 0.92 GAA (0.38) ALOX15ALOX12NPC1GAAATM
SCHEMBL2570309 0.91 ALOX15 (0.43) ALOX15ALOX12NPC1GAAATM
SCHEMBL2571971 0.90 ALOX15 (0.38) ALOX15ALOX12NPC1GAAATM
SCHEMBL10042946 0.89 ALOX15 (0.41) ALOX15ALOX12NPC1GAAATM
SCHEMBL2563485 0.88 ALOX15 (0.46) ALOX15ALOX12NPC1GAAATM
SCHEMBL13673338 0.86 SMN1; SMN2 (0.38) ALOX15ALOX12NPC1GAAATM
SCHEMBL2568306 0.85 ALOX15 (0.38) ALOX15ALOX12NPC1GAAATM
SCHEMBL13673358 0.84 ALOX15 (0.41) ALOX15ALOX12NPC1GAAATM
SCHEMBL2569873 0.82 ALOX15 (0.42) ALOX15ALOX12NPC1GAAATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160287555-A1 SUBSTITUTED CHROMAN DERIVATIVES, MEDICAMENTS AND USE IN THERAPY NOVOGEN RESEARCH PTY LTD (AU) 2016-10-06 — — US disclosed
US-9381186-B2 Substituted chroman derivatives, medicaments and use in therapy MEI PHARMA, INC. (US) 2016-07-05 — — US disclosed
US-20150352074-A1 SUBSTITUTED CHROMAN DERIVATIVES, MEDICAMENTS AND USE IN THERAPY NOVOGEN RESEARCH PTY LTD (AU) 2015-12-10 — — US disclosed
US-20120114766-A1 SUBSTITUTED CHROMAN DERIVATIVES, MEDICAMENTS AND USE IN THERAPY MARSHALL EDWARDS, INC. (US) 2012-05-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150352074-A1 SUBSTITUTED CHROMAN DERIVATIVES, MEDICAMENTS AND USE IN THERAPY CDYL, XPA, TP53 ALOX15 4170/4885ALOX12 4177/4885NPC1 2258/4885
US-20120114766-A1 SUBSTITUTED CHROMAN DERIVATIVES, MEDICAMENTS AND USE IN THERAPY CDYL, XPA, TP53 ALOX15 4170/4885ALOX12 4177/4885NPC1 2258/4885
US-20160287555-A1 SUBSTITUTED CHROMAN DERIVATIVES, MEDICAMENTS AND USE IN THERAPY CDYL, XPA, TP53 ALOX15 4170/4885ALOX12 4177/4885NPC1 2258/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.