ALOX15

Polyunsaturated fatty acid lipoxygenase ALOX15 · P16050 · ALOX15 on Sugi Atlas →

1,326,719 patent compounds predicted against ALOX15, 864,189 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Masoprocol (SCHEMBL3818)	1.00	9/20
SCHEMBL3160	0.90	7/20
SCHEMBL2390	0.85	6/20
Vinblastine (SCHEMBL3549)	1.00	5/20
Vinblastine (SCHEMBL3550)	1.00	5/20
Vinblastine (SCHEMBL3628)	1.00	5/20
Vinblastine (SCHEMBL3629)	1.00	5/20
Vincristine (SCHEMBL3709)	1.00	5/20
Vincristine (SCHEMBL3999)	1.00	5/20
Vinblastine (SCHEMBL6146)	1.00	5/20
Vincristine (SCHEMBL3710)	0.97	5/20
Vincristine (SCHEMBL3998)	0.97	5/20
Beta Carotene (SCHEMBL6151)	0.84	5/20
Vinzolidine (SCHEMBL4849)	0.80	5/20
Reserpine (SCHEMBL2589)	1.00	4/20
Vinepidine (SCHEMBL4076)	0.83	4/20
Vinflunine (SCHEMBL8403)	0.77	4/20
Vinflunine (SCHEMBL8404)	0.77	4/20
SCHEMBL3255	0.67	4/20
SCHEMBL3287	0.67	4/20

Clinical trials — most relevant to ALOX15 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Predicting Response to Standardized Pediatric Colitis Therapy	PHASE4	COMPLETED
The Effect of Ticagrelor on 15-Epi-Lipoxin A4 and Inflammation	PHASE4	WITHDRAWN
Diet Rich in N-3 Polyunsaturated Fatty Acids in Renal Transplant Recipients	PHASE4	COMPLETED
Atorvastatin, Aspirin, Oxidative Stress, Coagulation and Platelet Activation Indexes	PHASE4	UNKNOWN
Obesity and Asthma: Nutrigenetic Response to Omega-3 Fatty Acids	PHASE2/PHASE3	COMPLETED
Aspirin for Uncontrolled Asthma	PHASE3	COMPLETED
Chemoprevention Trial in Familial Adenomatous Polyposis (FAP) Coli Using EPA	PHASE2/PHASE3	COMPLETED
Montelukast for Early Life Wheezing	PHASE2/PHASE3	COMPLETED
GSK2190915 Neutrophilic Asthma Study	PHASE2	COMPLETED
Acute Pseudophakic Cystoid Macular Edema Treatment Trial: Intravitreal Ranibizumab Versus Triamcinolone Acetonide	PHASE1	COMPLETED
GSK2190915A - Bioavailability Study	PHASE1	COMPLETED
A Repeat Dose Study to Investigate the Interaction of GSK2190915 on the Pharmacokinetics of Rosuvastatin	PHASE1	COMPLETED
Role of 12-lipoxygenase in Platelet Reactivity and Type 2 Diabetes Mellitus	EARLY_PHASE1	COMPLETED
Heart & Health Study	nan	COMPLETED
Fish Oil to Prevent Asthma Exacerbations in Patients With ALOX5 Polymorphisms	nan	COMPLETED
Fatty Acid Regulation of Platelet Function in Diabetes	nan	COMPLETED
Lipidomics Screening of Anti-inflammatory Drugs and Drug Candidates in Vitro - Part A	nan	ACTIVE_NOT_RECRUITING
Lipidomics Screening of Celecoxib in ex Vivo Human Whole Blood Assay - Part B	nan	COMPLETED
PLatelets Acetyl-CoA Carboxylase Phosphorylation State in SEPtic Shock	nan	COMPLETED
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish)	nan	UNKNOWN
Eicosanoid Lipids by Airway Cells During Infection With Human Rhinoviruses	nan	COMPLETED
Fish Oil and Nonalcoholic Fatty Liver Disease (NAFLD) Study	nan	COMPLETED
Maresin-1 and Resolvin-D1 Levels and Disease Activity in Ulcerative Colitis	nan	COMPLETED
The Severe Asthma Research Program III-Boston Clinical Site	nan	COMPLETED
Oxidative Lipidomic Biomarkers During Mechanical Ventilation in Critically Ill Patients (OXY-BAL).	nan	RECRUITING
Study of the Arachidonate 5-Lipoxygenase Enzyme in Affecting the Risk for Coronary Heart Disease	nan	COMPLETED
Obesity, Inflammation and Aging: Effects of Physical Exercise and Omega-3 Fatty Acids.	nan	COMPLETED
The Comparison of Oxidative Stress Between Inhalation Anesthetics	nan	COMPLETED
Leukotrienes Pathway in Chinese Children With Sleep-disordered Breathing	nan	UNKNOWN
Investigation of Lipoxin A4, Annexin A1 and Interleukin-1 Beta Levels in Individuals With Periodontitis.	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ALOX15 binder may also engage these)

Protein	Name	Similarity
Q5RBE8	—	1.000	Q5RBE8 →
P27479	—	1.000	P27479 →
P55249	—	1.000	P55249 →
P12530	—	1.000	P12530 →
P16469	—	0.999	P16469 →
ALOX12	Polyunsaturated fatty acid lipoxygenase ALOX12	0.998	landscape →
F1LQ70	—	0.997	F1LQ70 →
D3ZQF9	—	0.996	D3ZQF9 →
P39655	—	0.995	P39655 →
Q02759	—	0.992	Q02759 →
Q9BYJ1	—	0.992	Q9BYJ1 →
D3ZKX9	—	0.988	D3ZKX9 →
Q9WV07	—	0.987	Q9WV07 →
P39654	—	0.985	P39654 →
ALOX15B	Polyunsaturated fatty acid lipoxygenase ALOX15B	0.981	landscape →
P48999	—	0.980	P48999 →
P12527	—	0.980	P12527 →
P51399	—	0.978	P51399 →
ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	0.977	landscape →
O75342	—	0.977	O75342 →
O35936	—	0.975	O35936 →
O70582	—	0.974	O70582 →
Q8K4F2	—	0.973	Q8K4F2 →
Q2KMM4	—	0.967	Q2KMM4 →
A6NFQ2	—	0.966	A6NFQ2 →
B2RUP2	—	0.964	B2RUP2 →
Q70J99	—	0.963	Q70J99 →
Q865R1	—	0.962	Q865R1 →
Q08DJ7	—	0.962	Q08DJ7 →
PARP3	Protein mono-ADP-ribosyltransferase PARP3	0.961	landscape →