Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.71 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | IL17A | Q16552 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15180060 | 0.84 | SYK (0.63) | SYKNPC1TSHRCYP2D6POLB | |
| SCHEMBL10196165 | 0.83 | SYK (1.00) | SYKNPC1TSHRCYP2D6POLB | |
| SCHEMBL12311750 | 0.80 | NPC1 (0.70) | SYKNPC1TSHRPOLBMEN1 | |
| SCHEMBL1911850 | 0.80 | NPC1 (0.66) | SYKNPC1TSHRPOLBMEN1 | |
| SCHEMBL12435658 | 0.80 | SYK (0.77) | SYKNPC1TSHRCYP2D6POLB | |
| SCHEMBL348270 | 0.79 | SYK (0.51) | SYKNPC1TSHRCYP2D6POLB | |
| SCHEMBL19227456 | 0.79 | POLB (0.71) | SYKNPC1CYP2D6POLBMEN1 | |
| SCHEMBL13791083 | 0.78 | SYK (0.59) | SYKNPC1TSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL616988 | 0.78 | BRD4 (0.51) | SYKBRD4IL17A | |
| SCHEMBL18639409 | 0.78 | MAPK1 (0.47) | ALDH1A1SMN1; SMN2BRD4PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012052420-A1 | METHOD FOR PREPARING SUBSTITUTED N-(3-AMINO-QUINOXALIN-2-YL)-SULFONAMIDES AND THEIR INTERMEDIATES N-(3-CHLORO-QUINOXALIN-2-YL)SULFONAMIDES | MERCK SERONO S.A. GENEVA (CH) | 2012-04-26 | — | — | WO | disclosed |