Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.77 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2087346 | 0.93 | CYP2D6 (0.71) | SYKTSHRCYP2D6HTR2BMEN1 | |
| SCHEMBL4038948 | 0.92 | CYP2D6 (0.65) | SYKTSHRCYP2D6MEN1KMT2A | |
| SCHEMBL2088116 | 0.92 | SYK (0.65) | SYKTSHRCYP2D6POLBHTR2C | |
| SCHEMBL10196165 | 0.87 | SYK (1.00) | SYKTSHRCYP2D6POLBMEN1 | |
| SCHEMBL6992013 | 0.87 | POLB (0.68) | SYKCYP2D6POLBHTR2CHTR2B | |
| SCHEMBL6314286 | 0.85 | SYK (0.56) | SYKTSHRCYP2D6POLBMEN1 | |
| SCHEMBL4036604 | 0.85 | CYP2D6 (0.60) | SYKTSHRCYP2D6HTR2BSMN1; SMN2 | |
| SCHEMBL2085669 | 0.83 | SYK (0.58) | SYKTSHRCYP2D6POLBHTR2C | |
| SCHEMBL212928 | 0.83 | HTR2C (0.59) | SYKTSHRCYP2D6POLBHTR2C | |
| SCHEMBL3426969 | 0.82 | SYK (0.59) | SYKCYP2D6POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011092128-A1 | SUBSTITUTED NAPHTHYRIDINES AND THEIR USE AS SYK KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-08-04 | — | — | WO | disclosed |