Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 11/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.67 |
| ▸ | MEN1 | O00255 | 5/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 3/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | CDC25A | P30304 | 1/20 | 0.61 |
| ▸ | CDC25B | P30305 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2304390 | 0.86 | RXFP1 (0.76) | RXFP1KDM4ENPSR1ALDH1A1MEN1 | |
| SCHEMBL3576814 | 0.85 | ALDH1A1 (0.78) | RXFP1KDM4ENPSR1ALDH1A1MEN1 | |
| SCHEMBL189044 | 0.84 | RXFP1 (1.00) | RXFP1KDM4ENPSR1ALDH1A1MEN1 | |
| SCHEMBL2302090 | 0.84 | RXFP1 (0.72) | RXFP1KDM4ENPSR1ALDH1A1MEN1 | |
| SCHEMBL2302089 | 0.84 | RXFP1 (0.73) | RXFP1KDM4ENPSR1ALDH1A1MEN1 | |
| SCHEMBL16154583 | 0.82 | RXFP1 (0.68) | RXFP1KDM4ENPSR1ALDH1A1MEN1 | |
| SCHEMBL15180084 | 0.81 | RXFP1 (0.67) | RXFP1KDM4ENPSR1ALDH1A1MEN1 | |
| SCHEMBL4346612 | 0.80 | CDC25A (0.52) | RXFP1KDM4ENPSR1ALDH1A1MEN1 | |
| SCHEMBL189621 | 0.80 | MEN1 (0.66) | RXFP1KDM4ENPSR1ALDH1A1MEN1 | |
| SCHEMBL15721518 | 0.79 | MEN1 (0.64) | RXFP1KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012052420-A1 | METHOD FOR PREPARING SUBSTITUTED N-(3-AMINO-QUINOXALIN-2-YL)-SULFONAMIDES AND THEIR INTERMEDIATES N-(3-CHLORO-QUINOXALIN-2-YL)SULFONAMIDES | MERCK SERONO S.A. GENEVA (CH) | 2012-04-26 | — | — | WO | disclosed |