SCHEMBL10044546

SCHEMBL10044546

CN(CCC(N)=O)c1ccc(C=O)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 2/20 0.48
CYP2A13 Q16696 1/20 0.48
ALDH1A1 P00352 7/20 0.46
ALDH3A1 P30838 1/20 0.46
ALDH1A3 P47895 1/20 0.46
MAPT P10636 3/20 0.37
KDM4E B2RXH2 2/20 0.37
GLA P06280 1/20 0.37
GAA P10253 1/20 0.37
HPGD P15428 1/20 0.37
GFER P55789 1/20 0.37
KMT2A Q03164 3/20 0.37
ADRA2A P08913 1/20 0.37
ADRA2B P18089 1/20 0.37
ADRA2C P18825 1/20 0.37
PARP10 Q53GL7 1/20 0.37
PARP3 Q9Y6F1 1/20 0.37
MEN1 O00255 1/20 0.36
POLB P06746 1/20 0.36
ALDH5A1 P51649 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8384383 0.85 CYP2A6 (0.50) CYP2A6CYP2A13ALDH1A1ALDH3A1ALDH1A3
SCHEMBL2557220 0.83 CYP2A6 (0.52) CYP2A6CYP2A13ALDH1A1ALDH3A1ALDH1A3
SCHEMBL13645995 0.82 CYP2A6 (0.64) CYP2A6CYP2A13ALDH1A1ALDH3A1ALDH1A3
SCHEMBL13306026 0.81 CYP2A6 (0.46) CYP2A6CYP2A13ALDH1A1ALDH3A1ALDH1A3
SCHEMBL11693529 0.81 CYP2A6 (0.46) CYP2A6CYP2A13ALDH1A1ALDH3A1ALDH1A3
SCHEMBL1033607 0.79 TP53 (0.44) ALDH1A1GLAKMT2AMEN1LTA4H
SCHEMBL62025 0.79 CYP2A6 (0.55) CYP2A6CYP2A13ALDH1A1ALDH3A1ALDH1A3
SCHEMBL20861927 0.79 CYP2A6 (0.55) CYP2A6CYP2A13ALDH1A1ALDH3A1ALDH1A3
SCHEMBL13645975 0.78 CYP2A6 (0.59) CYP2A6CYP2A13ALDH1A1ALDH3A1ALDH1A3
SCHEMBL12201383 0.77 ALDH1A1 (0.59) CYP2A6CYP2A13ALDH1A1ALDH3A1ALDH1A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130084561-A1 BIODETECTION BY NUCLEIC ACID-TEMPLATED CHEMISTRY COULL JAMES M (US) 2013-04-04 US disclosed
EP-2064348-B1 RECEPTOR FAMILY PROFILING ENSEMBLE THERAPEUTICS CORP (US) 2012-02-08 EP disclosed
US-8071388-B2 Compositions and methods for biodetection by nucleic acid-templated chemistry ENSEMBLE THERAPEUTICS CORPORATION (US) 2011-12-06 US disclosed
WO-2008054600-A2 COMPOSITIONS AND METHODS FOR BIODETECTION BY NUCLEIC ACID-TEMPLATED CHEMISTRY ENSEMBLE DISCOVERY CORPORATION (US) 2008-05-08 WO disclosed
WO-2008036273-A2 RECEPTOR FAMILY PROFILING ENSEMBLE DISCOVERY CORPORATION (US) 2008-03-27 WO disclosed
US-20070154899-A1 Biodetection by nucleic acid-templated chemistry ENSEMBLE THERAPEUTICS CORPORATION 2007-07-05 US disclosed