Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18639409 | 0.90 | MAPK1 (0.47) | L3MBTL1MAPTLMNAKDM4EMAPK1 | |
| SCHEMBL10044942 | 0.88 | BRD4 (0.48) | L3MBTL1MAPTLMNAKDM4EMAPK1 | |
| SCHEMBL15180055 | 0.80 | CA1 (0.41) | L3MBTL1MAPTLMNAKDM4EMAPK1 | |
| SCHEMBL10044605 | 0.80 | BRD4 (0.55) | L3MBTL1MAPTMAPK1BRD4CYP1A2 | |
| SCHEMBL18292053 | 0.78 | MAPK1 (0.58) | MAPK1ALDH1A1BRD4CYP1A2TNFRSF1A | |
| SCHEMBL15430852 | 0.77 | L3MBTL1 (0.56) | L3MBTL1MAPTLMNAKDM4EMAPK1 | |
| SCHEMBL10348410 | 0.75 | MAPT (0.51) | L3MBTL1MAPTLMNAKDM4EMEN1 | |
| SCHEMBL10348444 | 0.75 | MAPT (0.51) | L3MBTL1MAPTLMNAKDM4EMEN1 | |
| SCHEMBL10348443 | 0.75 | MAPT (0.51) | L3MBTL1MAPTLMNAKDM4EMEN1 | |
| SCHEMBL10349008 | 0.75 | MAPT (0.51) | L3MBTL1MAPTLMNAKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012052420-A1 | METHOD FOR PREPARING SUBSTITUTED N-(3-AMINO-QUINOXALIN-2-YL)-SULFONAMIDES AND THEIR INTERMEDIATES N-(3-CHLORO-QUINOXALIN-2-YL)SULFONAMIDES | MERCK SERONO S.A. GENEVA (CH) | 2012-04-26 | — | — | WO | disclosed |