Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 13/20 | 0.50 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | AR | P10275 | 11/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10045956 | 0.89 | PGR (0.50) | PGRNR3C1CHRM2CYP3A4OPRK1 | |
| SCHEMBL12539721 | 0.84 | PGR (0.46) | PGRNR3C1CHRM2CYP3A4OPRK1 | |
| SCHEMBL12558657 | 0.83 | PGR (0.66) | PGRNR3C1CHRM2CYP3A4OPRK1 | |
| SCHEMBL11029881 | 0.83 | PGR (0.66) | PGRNR3C1CHRM2CYP3A4OPRK1 | |
| SCHEMBL13936413 | 0.83 | PGR (0.66) | PGRNR3C1CHRM2CYP3A4OPRK1 | |
| SCHEMBL14256380 | 0.83 | PGR (0.66) | PGRNR3C1CHRM2CYP3A4OPRK1 | |
| SCHEMBL14256415 | 0.83 | PGR (0.66) | PGRNR3C1CHRM2CYP3A4OPRK1 | |
| SCHEMBL10355878 | 0.78 | PGR (0.55) | PGRNR3C1CHRM2CYP3A4OPRK1 | |
| SCHEMBL13342048 | 0.78 | PGR (0.55) | PGRNR3C1CHRM2CYP3A4OPRK1 | |
| SCHEMBL10045931 | 0.77 | PGR (0.72) | PGRNR3C1CHRM2CYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297177-B1 | C-RING-SUBSTITUTED PREGN-4-ENE-21,17-CARBOLACTONE, AND PHARMACEUTICAL PREPARATIONS COMPRISING THE LATTER | Bayer Pharma AG (DE) | 2012-06-20 | — | — | EP | disclosed |
| US-20110130371-A1 | C-ring-substituted pregn-4-ene-21,17-carbolactones, and pharmaceutical preparations comprising the same | BAYER SCHERING PHARMA AKTIENGESSELSCHAFT (DE) | 2011-06-02 | — | — | US | disclosed |
| US-20110130371-A1 | C-ring-substituted pregn-4-ene-21,17-carbolactones, and pharmaceutical preparations comprising the same | BAYER SCHERING PHARMA AKTIENGESSELSCHAFT (DE) | 2011-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110130371-A1 | C-ring-substituted pregn-4-ene-21,17-carbolactones, and pharmaceutical preparations comprising the same | NR5A1, NR3C2, HSD17B11 | PGR 44/4885NR3C1 16/4885CHRM2 565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.