Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A1 | P43005 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.34 |
| ▸ | GRM8 | O00222 | 1/20 | 0.33 |
| ▸ | GRM6 | O15303 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GSR | P00390 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.33 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.33 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16450883 | 1.00 | SLC1A1 (0.35) | SLC1A1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL16450887 | 1.00 | SLC1A1 (0.35) | SLC1A1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL17724338 | 0.85 | KMT2A (0.36) | SLC1A1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL130831 | 0.85 | SLC1A1 (0.52) | SLC1A1SLC7A5GRM8GRM6GRIN2D | |
| SCHEMBL1841835 | 0.85 | LTA4H (0.43) | SLC1A1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL172526 | 0.85 | SLC1A1 (0.52) | SLC1A1SLC7A5GRM8GRM6GRIN2D | |
| SCHEMBL10884958 | 0.85 | KMT2A (0.36) | SLC1A1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL1411236 | 0.85 | SLC1A1 (0.52) | SLC1A1SLC7A5GRM8GRM6GRIN2D | |
| SCHEMBL1654337 | 0.85 | LTA4H (0.43) | SLC1A1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL283240 | 0.85 | KMT2A (0.36) | SLC1A1HDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9738660-B2 | Selective inhibitors for protein kinases and pharmaceutical composition and use thereof | NATIONAL CHIAO TUNG UNIVERSITY (CN) | 2017-08-22 | — | — | US | disclosed |
| EP-2281006-B1 | CROSS-LINKERS AND THEIR USES | IMMUNOGEN INC (US) | 2017-08-02 | — | — | EP | disclosed |
| US-20160096848-A1 | SELECTIVE INHIBITORS FOR PROTEIN KINASES AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | NATIONAL CHIAO TUNG UNIVERSITY (CN) | 2016-04-07 | — | — | US | disclosed |
| US-20120022371-A1 | Compositions and methods for detecting and treating tumors containing acidic areas | SUMMERTON JAMES EDWARD (US) | 2012-01-26 | — | — | US | disclosed |
| US-8084610-B2 | Compositions and methods for detecting and treating tumors containing acidic areas | SUMMERTON JAMES EDWARD (US) | 2011-12-27 | — | — | US | disclosed |
| US-20080124274-A1 | Compositions and methods for detecting and treating tumors containing acidic areas | SUMMERTON JAMES EDWARD | 2008-05-29 | — | — | US | disclosed |
| US-20070286803-A1 | Compositions and methods for detecting and treating tumors containing acidic areas | SUMMERTON JAMES EDWARD | 2007-12-13 | — | — | US | disclosed |
| US-20070231256-A1 | Compositions and methods for detecting and treating tumors containing acidic areas | SUMMERTON JAMES E | 2007-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160096848-A1 | SELECTIVE INHIBITORS FOR PROTEIN KINASES AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | CSNK1A1, MAP3K1, PACSIN2 | SLC1A1 2108/4885HDAC3 2250/4885HDAC1 1287/4885 |
| US-20120022371-A1 | Compositions and methods for detecting and treating tumors containing acidic areas | CA1, CA14, CA12 | SLC1A1 1521/4885HDAC3 798/4885HDAC1 726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.