Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.35 |
| ▸ | LIPC | P11150 | 1/20 | 0.34 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL584707 | 0.90 | HTT (0.55) | HTTMAPTMAPK1ALDH3A1NPC1 | |
| SCHEMBL18406296 | 0.90 | HTT (0.48) | HTTMAPTMAPK1ALDH3A1MAPK14 | |
| SCHEMBL13886053 | 0.89 | KMT2A (0.35) | MAPTMAPK1ALDH3A1NPC1ALDH1A1 | |
| SCHEMBL14116535 | 0.86 | HTT (0.45) | HTTMAPTMAPK1ALDH3A1MAPK14 | |
| SCHEMBL14116543 | 0.85 | HTT (0.44) | HTTMAPTMAPK1ALDH3A1MAPK14 | |
| SCHEMBL10048290 | 0.84 | MAPK14 (0.39) | MAPK14NPC1ALDH1A1LMNANPSR1 | |
| SCHEMBL584850 | 0.83 | PTGER4 (0.46) | MAPK14NPC1TDP1ALDH1A1PIK3C3 | |
| SCHEMBL3915803 | 0.80 | MAPT (0.43) | HTTMAPTMAPK1NPC1ALDH1A1 | |
| SCHEMBL3915802 | 0.80 | MAPT (0.43) | HTTMAPTMAPK1NPC1ALDH1A1 | |
| SCHEMBL10048482 | 0.80 | MAPT (0.44) | HTTMAPTMAPK1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797077-B1 | BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF I | ASTRAZENECA AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| US-7566788-B2 | Crystalline forms | ASTRAZENECA AB (SE) | 2009-07-28 | — | — | US | disclosed |
| US-7550495-B2 | Compounds, compositions containing them, preparation thereof and uses thereof I | ASTRAZENECA AB (SE) | 2009-06-23 | — | — | US | disclosed |
| WO-2007108754-A1 | CRYSTALLINE FORMS OF N- {2-TERT -BUTYL -1- [ (4,4- DIF LUOROCYCLOHEXYL) METHYL] -LH-BENZIMIDAZOL-5- YL}ETHANESULFONAMIDE SALTS | ASTRAZENECA AB (SE) | 2007-09-27 | — | — | WO | disclosed |