Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.37 |
| ▸ | LIPC | P11150 | 1/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 2/20 | 0.36 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | TDO2 | P48775 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL584850 | 0.87 | PTGER4 (0.46) | MAPK14PIK3C3LIPCLIPGNAMPT | |
| SCHEMBL10048007 | 0.84 | HTT (0.42) | MAPK14PIK3C3LIPCLIPGNAMPT | |
| SCHEMBL13699497 | 0.83 | NAMPT (0.46) | NAMPTNPC1RORCLMNATP53 | |
| SCHEMBL584707 | 0.83 | HTT (0.55) | NPC1LMNAALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL3923613 | 0.76 | PTGER4 (0.47) | LIPCLIPGNPC1ANO1ALDH1A1 | |
| SCHEMBL10048485 | 0.76 | PTGER4 (0.47) | LIPCLIPGRORCANO1TP53 | |
| SCHEMBL13804940 | 0.75 | CNR1 (0.42) | RORCALDH1A1PTGER4 | |
| SCHEMBL5881733 | 0.75 | PTGER4 (0.56) | MAPK14PIK3C3LIPCLIPGNAMPT | |
| SCHEMBL584385 | 0.74 | CNR2 (0.48) | LIPCLIPGRORCANO1LMNA | |
| SCHEMBL24969514 | 0.74 | EGFR (0.41) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797077-B1 | BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF I | ASTRAZENECA AB (SE) | 2012-02-15 | — | — | EP | disclosed |