Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 11/20 | 0.45 |
| ▸ | JAK2 | O60674 | 10/20 | 0.45 |
| ▸ | JAK3 | P52333 | 9/20 | 0.45 |
| ▸ | TYK2 | P29597 | 7/20 | 0.45 |
| ▸ | PRKCI | P41743 | 1/20 | 0.43 |
| ▸ | AKT2 | P31751 | 1/20 | 0.43 |
| ▸ | PBK | Q96KB5 | 2/20 | 0.42 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22930983 | 0.70 | JAK1 (0.41) | JAK1JAK2JAK3TYK2PRKCI | |
| SCHEMBL101906 | 0.69 | JAK1 (0.42) | JAK1JAK2JAK3TYK2PRKCI | |
| SCHEMBL3453092 | 0.69 | PRKCI (0.67) | JAK1JAK2JAK3TYK2PRKCI | |
| SCHEMBL10187808 | 0.69 | PRKCI (0.49) | JAK1JAK2PRKCIAKT2PBK | |
| SCHEMBL15426656 | 0.68 | AKT2 (0.44) | JAK1JAK2JAK3TYK2PRKCI | |
| SCHEMBL14605151 | 0.68 | JAK1 (0.59) | JAK1JAK2JAK3TYK2CCNE1 | |
| SCHEMBL98681 | 0.67 | PRKCI (0.43) | JAK2JAK3PRKCIAKT2PBK | |
| SCHEMBL100483 | 0.67 | PRKCI (0.54) | JAK1JAK2JAK3TYK2PRKCI | |
| SCHEMBL2279760 | 0.67 | JAK3 (0.55) | JAK1JAK2JAK3TYK2PRKCI | |
| SCHEMBL101265 | 0.67 | PRKCI (0.50) | JAK2JAK3PRKCIAKT2PBK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426129-A1 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | Incyte Corporation (US) | 2012-03-07 | — | — | EP | claimed |