Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1005087 | 0.78 | BACE1 (0.42) | BACE1 | |
| SCHEMBL361206 | 0.73 | PDK2 (0.31) | — | |
| SCHEMBL361698 | 0.71 | BACE1 (0.51) | BACE1 | |
| SCHEMBL361964 | 0.69 | PGR (0.33) | — | |
| SCHEMBL8514606 | 0.58 | BACE1 (0.56) | BACE1 | |
| Hydrochloric Acid SCHEMBL8514073 | 0.58 | BACE1 (0.56) | BACE1 | |
| SCHEMBL12696388 | 0.56 | BACE1 (0.52) | BACE1 | |
| Hydrochloric Acid SCHEMBL8514068 | 0.54 | BACE1 (0.58) | BACE1 | |
| SCHEMBL360714 | 0.54 | BACE1 (0.53) | BACE1 | |
| SCHEMBL17068974 | 0.52 | BACE1 (0.43) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2456763-A1 | OXAZINE DERIVATIVES AND THEIR USE AS BACE INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | Novartis AG (CH) | 2012-05-30 | — | — | EP | disclosed |
| WO-2011009943-A1 | OXAZINE DERIVATIVES AND THEIR USE AS BACE INHIBITORS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |