Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | TLR4 | O00206 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7614074 | 0.94 | MAPK1 (0.45) | MAPK1MCL1KDM4EHSD17B10CA1 | |
| SCHEMBL3171 | 0.81 | MAPK1 (0.54) | MAPK1MCL1KDM4EHSD17B10CA1 | |
| SCHEMBL20303983 | 0.81 | MAPK1 (0.54) | MAPK1MCL1KDM4EHSD17B10CA1 | |
| SCHEMBL7305358 | 0.81 | MAPK1 (0.54) | MAPK1MCL1KDM4EHSD17B10CA1 | |
| SCHEMBL181879 | 0.81 | CYP2D6 (0.48) | MAPK1MCL1KDM4EHSD17B10CA1 | |
| SCHEMBL1149626 | 0.80 | CYP2D6 (0.47) | MAPK1MCL1KDM4EHSD17B10CA1 | |
| SCHEMBL10080626 | 0.80 | CYP2D6 (0.47) | MAPK1MCL1KDM4EHSD17B10CA1 | |
| SCHEMBL1615850 | 0.79 | MAPK1 (0.53) | MAPK1MCL1KDM4EHSD17B10CA1 | |
| SCHEMBL6248372 | 0.79 | MAPK1 (0.53) | MAPK1MCL1KDM4EHSD17B10CA1 | |
| SCHEMBL3767660 | 0.79 | MAPK1 (0.53) | MAPK1MCL1KDM4EHSD17B10CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110118236-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-05-19 | — | — | US | disclosed |
| EP-2269990-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2011-01-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118236-A1 | HETEROCYCLIC COMPOUND | GRIN1, GRM1, GRIK1 | MAPK1 797/4885MCL1 1105/4885KDM4E 3157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.