Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | GLA | P06280 | 2/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10503868 | 0.84 | HSD17B10 (0.46) | HSD17B10CYP1A2CYP2C9KDM4EGAA | |
| SCHEMBL7367241 | 0.81 | GAA (0.51) | CYP1A2KDM4EGAAGLAMMP2 | |
| SCHEMBL8236144 | 0.79 | GAA (0.53) | CYP1A2KDM4EGAAGLAMMP2 | |
| SCHEMBL28618725 | 0.79 | GAA (0.53) | CYP1A2KDM4EGAAGLAMMP2 | |
| SCHEMBL28637393 | 0.77 | HSD17B10 (0.41) | HSD17B10CYP1A2CYP2C9KDM4EALDH1A1 | |
| SCHEMBL28618722 | 0.76 | KDM4E (0.50) | HSD17B10CYP1A2KDM4EGAAGLA | |
| SCHEMBL70624 | 0.75 | GAA (0.67) | HSD17B10CYP1A2KDM4EGAAGLA | |
| SCHEMBL13141200 | 0.75 | GAA (0.49) | HSD17B10CYP1A2KDM4EGAAGLA | |
| SCHEMBL6178828 | 0.73 | KDM4E (0.47) | HSD17B10CYP1A2KDM4EGAAGLA | |
| SCHEMBL6902078 | 0.73 | GAA (0.55) | CYP1A2KDM4EGAAGLAMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7902252-B2 | Inhibitors of D-amino acid oxidase | SEPRACOR, INC. (US) | 2011-03-08 | — | — | US | disclosed |
| WO-2011011330-A2 | INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2011-01-27 | — | — | WO | disclosed |
| US-20100029737-A1 | INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2010-02-04 | — | — | US | disclosed |
| CN-101636384-A | The inhibitor of D-amino-acid oxidase | SEPRACOR INC | 2010-01-27 | — | — | CN | disclosed |
| EP-2074092-A2 | INHIBITORS OF D-AMINO ACID OXIDASE | Sepracor Inc. (US) | 2009-07-01 | — | — | EP | disclosed |
| US-20090099248-A1 | INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2009-04-16 | — | — | US | disclosed |
| WO-2008089453-A2 | INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2008-07-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099248-A1 | INHIBITORS OF D-AMINO ACID OXIDASE | DDO, DAO, ACHE | HSD17B10 1605/4885CYP1A2 2041/4885CYP2C9 2411/4885 |
| US-20100029737-A1 | INHIBITORS OF D-AMINO ACID OXIDASE | DDO, DAO, ACHE | HSD17B10 1605/4885CYP1A2 2041/4885CYP2C9 2411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.