ACHE

Acetylcholinesterase · P22303 · ACHE on Sugi Atlas →

709,542 patent compounds predicted against ACHE, 395,252 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Rivastigmine (SCHEMBL2764)	1.00	17/20
Rivastigmine (SCHEMBL2763)	1.00	16/20
Tacrine (SCHEMBL2828)	1.00	16/20
Tacrine (SCHEMBL3270)	1.00	16/20
Ranitidine (SCHEMBL824)	1.00	15/20
Ranitidine (SCHEMBL825)	1.00	15/20
Ranitidine (SCHEMBL826)	1.00	15/20
Physostigmine (SCHEMBL24044)	1.00	14/20
Physostigmine (SCHEMBL24045)	1.00	14/20
Propomocarb (SCHEMBL21077)	0.61	14/20
Pyridostigmine (SCHEMBL1317)	1.00	11/20
Berberine (SCHEMBL25632)	1.00	10/20
Donepezil (SCHEMBL2149)	1.00	8/20
Donepezil (SCHEMBL3516)	1.00	8/20
Donepezil (SCHEMBL2850)	0.96	8/20
SCHEMBL27247	0.52	8/20
SCHEMBL3892	0.48	8/20
Nizatidine (SCHEMBL769)	1.00	7/20
Nizatidine (SCHEMBL770)	1.00	7/20
Iodide (SCHEMBL14996)	1.00	7/20

Clinical trials — most relevant to ACHE by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Detecting an Early Response to Donepezil With Measures of Visual Attention	PHASE4	COMPLETED
Galantamine for Cognition in People With Schizophrenia	PHASE4	COMPLETED
The Effect of Thai Traditional Music on Cognitive Function, Psychological Health and Quality of Sleep Among Thai Older Individuals With Dementia	PHASE3	COMPLETED
Study of Idalopirdine in Patients With Mild - Moderate Alzheimer's Disease Treated With an Acetylcholinesterase Inhibitor	PHASE3	COMPLETED
Study To Evaluate the Efficacy, Safety and Tolerability of E2027 (Hereinafter Referred to as Irsenontrine) in Participants With Dementia With Lewy Bodies	PHASE2	COMPLETED
Recovery Times of Half Dose Sugammadex and Neostigmine for Rocuronium-induced Neuromuscular Blockade	PHASE1/PHASE2	RECRUITING
Safety Study of Pyridostigmine in Heart Failure	PHASE2	COMPLETED
Effect of Insulin Sensitizer Metformin on AD Biomarkers	PHASE2	COMPLETED
Acetylcholinesterase Inhibition and Orthostatic Hypotension in SCI	PHASE2	COMPLETED
Adjuvant Use of Neostigmine in Sepsis and Septic Shock.	PHASE2	COMPLETED
Mayo Acute Stroke Trial for Enhancing Recovery	PHASE2	COMPLETED
Tacrine Effects on Cocaine Self-Administration and Pharmacokinetics	PHASE2	WITHDRAWN
Riluzole in Mild Alzheimer's Disease	PHASE2	COMPLETED
Bisnorcymserine in Healthy Adult Volunteers	PHASE1	COMPLETED
Efficacy of Intrathecal Clonidine Versus Neostigmine as Adjuvants to Bupivacaine on Postoperative Maternal and Fetal Outcomes After Elective Cesarean Section	PHASE1	UNKNOWN
Multiple Ascending Dose Putative Cognitive Enhancer VU319	PHASE1	WITHDRAWN
A Study of Possibility of Using Regulatory T Cells(VT301) for Treatment of Alzheimer's Disease	PHASE1	UNKNOWN
A Phase 1 Study of the Safety, Tolerability and Pharmacokinetics of ABT-126 in Subjects With Alzheimer's Disease	PHASE1	COMPLETED
Putative Cognitive Enhancer VU319	PHASE1	COMPLETED
The Effect of Physostigmine on Cognitive Functioning in the Immediate Period After Sedation for Colonoscopy	nan	UNKNOWN
Cholinergic Markers Alzheimer's Disease	nan	COMPLETED
Value of Butyrylcholinesterase as a Marker of Surgical Site Infection Following Surgery for Colorectal Diseases	nan	COMPLETED
Cholinesterase, Amylase, Lipase and Neutrophil-to-lymphocyte Ratio in Acute Pesticide Poisoning Cases	nan	UNKNOWN
Electroconvulsive Therapy for Treatment of Alzheimer´s Disease	nan	NOT_YET_RECRUITING
Acrylamide and Health Outcomes	nan	COMPLETED
Cognitive Changes in Alzheimer's Disease Patients Associated With or Without White Matter Changes After Rivastigmine	nan	COMPLETED
Sugammadex/Neostigmine and Liver Transplantation	nan	COMPLETED
Reversal of Neuromuscular Blockade in Thoracic Surgical Patients	nan	COMPLETED
Imaging Biomarkers of Progression of Mobility Impairment in Parkinson Disease	nan	COMPLETED
Aerobic Exercise in Parkinson's Disease	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ACHE binder may also engage these)

Protein	Name	Similarity
P23795	—	1.000	P23795 →
P21836	—	1.000	P21836 →
P37136	—	1.000	P37136 →
O62763	—	0.999	O62763 →
Q29499	—	0.996	Q29499 →
Q92035	—	0.985	Q92035 →
CES2	Cocaine esterase	0.982	landscape →
Q6UWW8	—	0.981	Q6UWW8 →
Q5RCL7	—	0.981	Q5RCL7 →
Q63880	—	0.978	Q63880 →
Q91WG0	—	0.978	Q91WG0 →
P14943	—	0.978	P14943 →
Q8VCC2	—	0.977	Q8VCC2 →
Q8K3R0	—	0.976	Q8K3R0 →
Q6AW47	—	0.976	Q6AW47 →
Q69ZK9	—	0.974	Q69ZK9 →
Q8R0W5	—	0.974	Q8R0W5 →
Q6NT32	—	0.974	Q6NT32 →
Q29550	—	0.974	Q29550 →
O46421	—	0.974	O46421 →
Q8BK48	—	0.973	Q8BK48 →
Q13724	—	0.973	Q13724 →
Q64419	—	0.973	Q64419 →
Q86GC8	—	0.973	Q86GC8 →
P51840	—	0.973	P51840 →
Q62888	—	0.973	Q62888 →
Q63108	—	0.972	Q63108 →
Q8BYM5	—	0.972	Q8BYM5 →
P10959	—	0.972	P10959 →
P0DPE2	—	0.972	P0DPE2 →