Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 6/20 | 0.60 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
| ▸ | HRH2 | P25021 | 6/20 | 0.42 |
| ▸ | HRH1 | P35367 | 6/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | KLK7 | P49862 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL490684 | 0.95 | CACNA1B (0.59) | CACNA1BITGB3ITGA2BHRH2HRH1 | |
| SCHEMBL8257659 | 0.90 | CACNA1B (0.51) | CACNA1BITGB3ITGA2BHRH2HRH1 | |
| SCHEMBL2740535 | 0.90 | CACNA1B (0.51) | CACNA1BITGB3ITGA2BHRH2HRH1 | |
| SCHEMBL13667331 | 0.88 | CACNA1B (0.52) | CACNA1BAAK1ALDH1A1CTSSCTSK | |
| SCHEMBL192978 | 0.88 | CACNA1B (0.54) | CACNA1BITGB3ITGA2BHRH2HRH1 | |
| SCHEMBL14066762 | 0.88 | CACNA1B (0.49) | CACNA1BITGB3ITGA2BHRH2HRH1 | |
| SCHEMBL13421977 | 0.88 | CACNA1B (0.49) | CACNA1BITGB3ITGA2BHRH2HRH1 | |
| SCHEMBL192979 | 0.88 | CACNA1B (0.54) | CACNA1BITGB3ITGA2BHRH2HRH1 | |
| SCHEMBL193382 | 0.86 | CACNA1B (0.48) | CACNA1BITGB3ITGA2BHRH2HRH1 | |
| SCHEMBL193381 | 0.86 | CACNA1B (0.48) | CACNA1BITGB3ITGA2BHRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106091-B2 | Inhibitors of IKK-beta serine-threonine protein kinase | CHROMA THERAPEUTICS LTD. (GB) | 2012-01-31 | — | — | US | disclosed |
| US-20100069473-A1 | Inhibitors Of IKK-Beta Serine-Threonine Protein Kinase | CHROMA THERAPEUTICS LTD. (GB) | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069473-A1 | Inhibitors Of IKK-Beta Serine-Threonine Protein Kinase | IKBKB, IKBKE, CHUK | CACNA1B 2344/4885ITGB3 2310/4885ITGA2B 3707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.