Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 5/20 | 0.52 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.39 |
| ▸ | KLK7 | P49862 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL193352 | 0.89 | CACNA1B (0.52) | CACNA1BAAK1KDM4EALDH1A1KLK7 | |
| SCHEMBL193351 | 0.89 | CACNA1B (0.52) | CACNA1BAAK1KDM4EALDH1A1KLK7 | |
| SCHEMBL10052884 | 0.88 | CACNA1B (0.60) | CACNA1BCTSSCTSKAAK1ALDH1A1 | |
| SCHEMBL193656 | 0.85 | CACNA1B (0.49) | CACNA1BRAB9AMEN1KMT2APOLB | |
| SCHEMBL193655 | 0.85 | CACNA1B (0.49) | CACNA1BRAB9AMEN1KMT2APOLB | |
| SCHEMBL1147671 | 0.84 | CACNA1B (0.47) | CACNA1BAAK1KLK7 | |
| SCHEMBL490684 | 0.83 | CACNA1B (0.59) | CACNA1BCTSSCTSKAAK1ALDH1A1 | |
| SCHEMBL192979 | 0.83 | CACNA1B (0.54) | CACNA1BALDH1A1KLK7LMNA | |
| SCHEMBL192978 | 0.83 | CACNA1B (0.54) | CACNA1BALDH1A1KLK7LMNA | |
| SCHEMBL8257659 | 0.82 | CACNA1B (0.51) | CACNA1BAAK1KLK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009130434-A1 | INHIBITORS OF IKK-β SERINE-THREONINE PROTEIN KINASE | CHROMA THERAPEUTICS LTD. (GB) | 2009-10-29 | — | — | WO | disclosed |