Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.51 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.48 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5225799 | 0.82 | PARP1 (0.64) | PARP1PARP10CA1CA2PARP2 | |
| SCHEMBL894796 | 0.82 | PARP1 (0.64) | PARP1PARP10CA1CA2PARP2 | |
| SCHEMBL11957888 | 0.78 | ALDH1A1 (0.58) | KDM4EHTTMAPTPOLBKMT2A | |
| SCHEMBL19828394 | 0.76 | PARP1 (0.56) | PARP1PARP10CA1CA2PARP2 | |
| SCHEMBL14192803 | 0.76 | PARP1 (0.56) | PARP1PARP10CA1CA2PARP2 | |
| SCHEMBL3087859 | 0.76 | PARP1 (0.56) | PARP1PARP10CA1CA2PARP2 | |
| SCHEMBL23360890 | 0.74 | PARP1 (0.55) | PARP1PARP10CA1CA2PARP2 | |
| SCHEMBL1362735 | 0.74 | PARP1 (0.55) | PARP1PARP10CA1CA2PARP2 | |
| SCHEMBL6171991 | 0.74 | PARP1 (0.59) | PARP1PARP10CA1CA2PARP2 | |
| SCHEMBL29826907 | 0.74 | PARP1 (0.55) | PARP1PARP10CA1CA2PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120053208-A1 | Curcumin Analogs as Dual JAK2/STAT3 Inhibitors and Methods of Making and Using the Same | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053208-A1 | Curcumin Analogs as Dual JAK2/STAT3 Inhibitors and Methods of Making and Using the Same | JAK2, STAT3, STAT5B | PARP1 1850/4885PARP10 1401/4885CA1 3074/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.