Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF4A1 | P60842 | 18/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | RELA | Q04206 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.80 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.80 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rocaglamide SCHEMBL29439568 | 1.00 | EIF4A1 (1.00) | EIF4A1NFKB1RELACYP3A4HIF1A | |
| Rocaglamide SCHEMBL751061 | 1.00 | EIF4A1 (1.00) | EIF4A1NFKB1RELACYP3A4HIF1A | |
| Rocaglamide SCHEMBL752144 | 1.00 | EIF4A1 (1.00) | EIF4A1NFKB1RELACYP3A4HIF1A | |
| Rocaglamide SCHEMBL20386162 | 1.00 | EIF4A1 (1.00) | EIF4A1NFKB1RELACYP3A4HIF1A | |
| Rocaglamide SCHEMBL29407815 | 1.00 | EIF4A1 (1.00) | EIF4A1NFKB1RELACYP3A4HIF1A | |
| Rocaglamide SCHEMBL24127774 | 1.00 | EIF4A1 (1.00) | EIF4A1NFKB1RELACYP3A4HIF1A | |
| SCHEMBL12182311 | 0.93 | EIF4A1 (0.87) | EIF4A1NFKB1RELACYP3A4HIF1A | |
| SCHEMBL29370550 | 0.91 | EIF4A1 (0.84) | EIF4A1NFKB1RELACYP3A4HIF1A | |
| SCHEMBL15079078 | 0.91 | EIF4A1 (0.86) | EIF4A1NFKB1RELACYP3A4HIF1A | |
| Rocagloic Acid SCHEMBL750035 | 0.91 | EIF4A1 (0.86) | EIF4A1NFKB1RELACYP3A4HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037062-A2 | NEW ROUTE TO SYNTHETIC ANALOGUES OF ROCAGLAMIDE AND AGLAFOLINE USING CASCADE TRANSFORMATIONS INITIATED BY OXY-COPE REARRANGEMENTS OF BIS-ALKYNES | FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2012-03-22 | — | — | WO | disclosed |