Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 18/20 | 0.86 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.80 |
| ▸ | MEN1 | O00255 | 3/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.80 |
| ▸ | TP53 | P04637 | 2/20 | 0.80 |
| ▸ | GLA | P06280 | 2/20 | 0.80 |
| ▸ | HPGD | P15428 | 2/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.80 |
| ▸ | HBB | P68871 | 2/20 | 0.80 |
| ▸ | STAT6 | P42226 | 1/20 | 0.80 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.80 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.80 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.80 |
| ▸ | GMNN | O75496 | 1/20 | 0.80 |
| ▸ | LMNA | P02545 | 1/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.80 |
| ▸ | HNRNPA1 | P09651 | 1/20 | 0.80 |
| ▸ | GAA | P10253 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27670515 | 1.00 | TOP1 (0.86) | TOP1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL17145878 | 0.93 | TOP1 (1.00) | TOP1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL1007394 | 0.93 | TOP1 (1.00) | TOP1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL30803850 | 0.91 | TOP1 (0.86) | TOP1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL27702297 | 0.91 | TOP1 (0.86) | TOP1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL935913 | 0.91 | TOP1 (0.86) | TOP1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL31726279 | 0.90 | TOP1 (0.87) | TOP1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL7258212 | 0.90 | TOP1 (0.87) | TOP1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL8322065 | 0.90 | TOP1 (0.87) | TOP1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL6366926 | 0.90 | TOP1 (0.87) | TOP1KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 164 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118239956-A | Preparation of 11-fluorocamptothecin derivative and application thereof in anti-tumor aspect | 兰州大学 | 2024-06-25 | — | — | CN | claimed |
| EP-1556010-A4 | PHARMACEUTICAL FORMULATIONS TARGETING SPECIFIC REGIONS OF THE GASTROINTESTINAL TRACT | SUPERGEN INC (US) | 2007-12-05 | — | — | EP | claimed |
| EP-1556010-A2 | PHARMACEUTICAL FORMULATIONS TARGETING SPECIFIC REGIONS OF THE GASTROINTESTINAL TRACT | SuperGen, Inc. (US) | 2005-07-27 | — | — | EP | claimed |
| US-20040162263-A1 | Pharmaceutical formulations targeting specific regions of the gastrointesinal tract | SUPERGEN, INC., A DELAWARE CORPORATION | 2004-08-19 | — | — | US | claimed |
| WO-2004041195-A2 | PHARMACEUTICAL FORMULATIONS TARGETING SPECIFIC REGIONS OF THE GASTROINTESTINAL TRACT | SUPERGEN, INC. (US) | 2004-05-21 | — | — | WO | claimed |
| EP-1365705-A1 | INJECTABLE PHARMACEUTICAL COMPOSITION COMPRISING MICROPARTICLES OR MICRODROPLETS OF CAMPTOTHECIN | SuperGen, Inc. (US) | 2003-12-03 | — | — | EP | claimed |
| EP-1311266-A2 | COMBINATION HIV THERAPY INCLUDING CAMPTOTHECIN | SuperGen, Inc. (US) | 2003-05-21 | — | — | EP | claimed |
| US-6534080-B2 | Injecting into a patientaqueous suspension of solid particles suitable for intravenous delivery, the solid particles comprising a camptothecin, and a 0.3 nm to 3.0 mu m thick layer of a membrane-forming amphipathic lipid | SUPER GEN, INC. | 2003-03-18 | — | — | US | claimed |
| US-6509027-B2 | Anticancer agent | SUPERGEN, INC. | 2003-01-21 | — | — | US | claimed |
| US-6497896-B2 | AQUEOUS SUSPENSION; THERMAL STERILIZATION | SUPERGEN, INC. | 2002-12-24 | — | — | US | claimed |
| US-20020150615-A1 | Injectable pharmaceutical composition comprising microdroplets of a camptothecin | SKYEPHARMA AG (CH) | 2002-10-17 | — | — | US | claimed |
| US-20020147202-A1 | Method for administering camptothecins via injection of a pharmaceutical composition comprising microdroplets containing a camptothecin | RTP PHARMA INC. (CA) | 2002-10-10 | — | — | US | claimed |
| US-20020146460-A1 | Method for administering camptothecins VIA injection of pharmaceutical composition comprising coated particles of a camptothecin | ASTEX PHARMACEUTICALS, INC. | 2002-10-10 | — | — | US | claimed |
| US-20020142048-A1 | Injectable pharmaceutical composition comprising coated particles of camptothecin | ASTEX PHARMACEUTICALS, INC. | 2002-10-03 | — | — | US | claimed |
| WO-2002064064-A1 | INJECTABLE PHARMACEUTICAL COMPOSITION COMPRISING MICROPARTICLES OR MICRODROPLETS OF CAMPTOTHECIN | SUPERGEN, INC. (US) | 2002-08-22 | — | — | WO | claimed |
| WO-2002000168-A2 | COMBINATION HIV THERAPY INCLUDING CAMPTOTHECIN | SUPERGEN, INC. (US) | 2002-01-03 | — | — | WO | claimed |
| CN-118239956-A | Preparation of 11-fluorocamptothecin derivative and application thereof in anti-tumor aspect | 兰州大学 | 2024-06-25 | — | — | CN | disclosed |
| CN-118239956-A | Preparation of 11-fluorocamptothecin derivative and application thereof in anti-tumor aspect | 兰州大学 | 2024-06-25 | — | — | CN | disclosed |
| US-5726181-A | Formulations and compositions of poorly water soluble camptothecin derivatives | BIONUMERIK PHARMACEUTICALS, INC. (US) | 1998-03-10 | — | — | US | disclosed |
| WO-1996039143-A1 | PHARMACEUTICAL FORMULATIONS OF HIGHLY LIPOPHILIC CAMPTOTHECIN DERIVATIVES | BIONUMERIK PHARMACEUTICALS, INC. (US) | 1996-12-12 | — | — | WO | disclosed |