Sugi Predict

Sugi Predict / Compounds / SCHEMBL935913

SCHEMBL935913

SCHEMBL935913

CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3ccc(O)cc3nc2-1

nearest known ligand 0.86

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TOP1 P11387 18/20 0.86
▸ MEN1 O00255 4/20 0.86
▸ KMT2A Q03164 4/20 0.86
▸ SMN1; SMN2 Q16637 4/20 0.86
▸ ALDH1A1 P00352 4/20 0.86
▸ KDM4E B2RXH2 3/20 0.86
▸ CYP3A4 P08684 2/20 0.86
▸ HBB P68871 2/20 0.86
▸ CASP1 P29466 1/20 0.86
▸ CASP7 P55210 1/20 0.86
▸ GLA P06280 3/20 0.80
▸ TP53 P04637 2/20 0.80
▸ HPGD P15428 2/20 0.80
▸ STAT6 P42226 1/20 0.80
▸ CHEK1 O14757 1/20 0.80
▸ HDAC3 O15379 1/20 0.80
▸ ABCC4 O15439 1/20 0.80
▸ GMNN O75496 1/20 0.80
▸ LMNA P02545 1/20 0.80
▸ CYP1A2 P05177 1/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27702297 1.00 TOP1 (0.86) TOP1MEN1KMT2ASMN1; SMN2ALDH1A1
SCHEMBL30803850 1.00 TOP1 (0.86) TOP1MEN1KMT2ASMN1; SMN2ALDH1A1
Camptothecin SCHEMBL20336238 0.96 TOP1 (0.88) TOP1MEN1KMT2ASMN1; SMN2ALDH1A1
Hydroxycamptothecin SCHEMBL29350707 0.93 TOP1 (1.00) TOP1MEN1KMT2ASMN1; SMN2ALDH1A1
Hydroxycamptothecin SCHEMBL9384413 0.93 TOP1 (1.00) TOP1MEN1KMT2ASMN1; SMN2ALDH1A1
Hydroxycamptothecin SCHEMBL25875 0.93 TOP1 (1.00) TOP1MEN1KMT2ASMN1; SMN2ALDH1A1
Hydroxycamptothecin SCHEMBL29929278 0.93 TOP1 (1.00) TOP1MEN1KMT2ASMN1; SMN2ALDH1A1
Hydroxycamptothecin SCHEMBL30872708 0.92 TOP1 (0.98) TOP1MEN1KMT2ASMN1; SMN2ALDH1A1
Hydroxycamptothecin SCHEMBL27713853 0.92 TOP1 (0.98) TOP1MEN1KMT2ASMN1; SMN2ALDH1A1
Hydroxycamptothecin SCHEMBL30426602 0.92 TOP1 (0.98) TOP1MEN1KMT2ASMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 195 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240084272-A1 CYTOCHROME P450 MONOOXYGENASES AND USES THEREOF UNIV BRITISH COLUMBIA (CA) 2024-03-14 — — US claimed
WO-2022120490-A1 CYTOCHROME P450 MONOOXYGENASES AND USES THEREOF THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2022-06-16 — — WO claimed
US-7994186-B2 Pharmaceutical compositions containing camptothecins KABUSHIKI KAISHA YAKULT HONSHA (JP) 2011-08-09 — — US claimed
CN-101385860-A Camptothecine and non-linear polyethyleneglycol prodrug of derivative thereof AMERICAN CAOYAOQUAN CO LTD (US) 2009-03-18 — — CN claimed
US-6011042-A POLYMERIC PRODRUGS ARE PREFERABLY ESTERS OF HYDROXYL-CONTAINING AROMATIC COMPOUNDS AND ARE FORMED BY REACTING A DESIRED AROMATIC, HYDROXYL-CONTAINING COMPOUND WITH A SUBSTANTIALLY NON-ANTIGENIC POLYMER ENZON, INC. (US) 2000-01-04 — — US claimed
US-20240084272-A1 CYTOCHROME P450 MONOOXYGENASES AND USES THEREOF UNIV BRITISH COLUMBIA (CA) 2024-03-14 — — US disclosed
US-11672776-B2 Multi-arm polymeric alkanoate conjugates NEKTAR THERAPEUTICS (US) 2023-06-13 — — US disclosed
CN-115505472-A Brewing process of health wine containing camptotheca acuminate and ginseng 上海正数新能源科技有限公司 2022-12-23 — — CN disclosed
CN-115443134-A Conjugates of cell binding molecules and camptothecin analogs 杭州多禧生物科技有限公司 2022-12-06 — — CN disclosed
WO-2022120490-A1 CYTOCHROME P450 MONOOXYGENASES AND USES THEREOF THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2022-06-16 — — WO disclosed
US-20220079936-A1 MULTI-ARM POLYMER PRODRUGS NEKTAR THERAPEUTICS (US) 2022-03-17 — — US disclosed
CN-108484617-B Novel benzofuran azanaphthalene dione derivative and preparation method thereof 爱斯特（成都）生物制药股份有限公司 2021-08-31 — — CN disclosed
EP-0436653-A1 SYNTHESIS OF CAMPTOTHECIN AND ANALOGS THEREOF RESEARCH TRIANGLE INSTITUTE (US) 1991-07-17 — — EP disclosed
WO-1991005556-A1 CAMPTOTHECIN ANALOGS AS POTENT INHIBITORS OF HUMAN COLORECTAL CANCER RESEARCH TRIANGLE INSTITUTE (US) 1991-05-02 — — WO disclosed
US-4981968-A ENZYME INHIBITORS, ANTITUMOR RESEARCH TRIANGLE INSTITUTE (US) 1991-01-01 — — US disclosed
WO-1990003169-A1 SYNTHESIS OF CAMPTOTHECIN AND ANALOGS THEREOF RESEARCH TRIANGLE INSTITUTE (US) 1990-04-05 — — WO disclosed
US-4894456-A CYCLIZATION, ESTERIFICATION RESEARCH TRIANGLE INSTITUTE (US) 1990-01-16 — — US disclosed
EP-0137145-B1 NEW CAMPTOTHECIN DERIVATIVES AND PROCESS FOR PREPARING SAME KABUSHIKI KAISHA YAKULT HONSHA (JP) 1988-04-27 — — EP disclosed
US-4604463-A ANTITUMOR AGENTS KABUSHIKI KAISHA YAKULT HONSHA (JP) 1986-08-05 — — US disclosed
EP-0137145-A1 New camptothecin derivatives and process for preparing same KABUSHIKI KAISHA YAKULT HONSHA (JP) 1985-04-17 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11672776-B2 Multi-arm polymeric alkanoate conjugates ALK, ALKBH3, PAICS TOP1 161/4885MEN1 3463/4885KMT2A 723/4885
US-20240084272-A1 CYTOCHROME P450 MONOOXYGENASES AND USES THEREOF CYP3A43, CYP11B2, CYP11B1 TOP1 367/4885MEN1 2868/4885KMT2A 3443/4885
US-20220079936-A1 MULTI-ARM POLYMER PRODRUGS PAICS, CD38, ENTPD1 TOP1 747/4885MEN1 2709/4885KMT2A 1565/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.