Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS11D | O60235 | 12/20 | 0.51 |
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 4/20 | 0.45 |
| ▸ | F10 | P00742 | 4/20 | 0.45 |
| ▸ | PLG | P00747 | 3/20 | 0.45 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.43 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12968487 | 0.93 | TMPRSS11D (0.53) | TMPRSS11DACEF2F10PLG | |
| SCHEMBL10058308 | 0.87 | TMPRSS11D (0.52) | TMPRSS11DACEF2F10PLG | |
| SCHEMBL10058299 | 0.85 | TMPRSS11D (0.47) | TMPRSS11DACEF2F10PLG | |
| SCHEMBL15139686 | 0.84 | TMPRSS11D (0.50) | TMPRSS11DACEF2F10PLG | |
| SCHEMBL19390410 | 0.83 | TMPRSS11D (0.50) | TMPRSS11DACEF2F10PLG | |
| SCHEMBL19390241 | 0.81 | ACE (0.53) | TMPRSS11DACELTA4H | |
| SCHEMBL15251724 | 0.80 | FKBP1A (0.52) | TMPRSS11DACEF2F10PLG | |
| SCHEMBL15251707 | 0.80 | FKBP1A (0.52) | TMPRSS11DACEF2F10PLG | |
| SCHEMBL15251708 | 0.80 | FKBP1A (0.52) | TMPRSS11DACEF2F10PLG | |
| SCHEMBL10059236 | 0.80 | TMPRSS11D (0.60) | TMPRSS11DACEF2F10PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012083436-A1 | TRYPSIN-LIKE SERINE PROTEASE INHIBITORS, THEIR PREPARATION AND USE AS SELECTIVE INHIBITORS OF THE CLOTTING FACTORS IIA AND XA | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2012-06-28 | — | — | WO | disclosed |