Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 10/20 | 0.74 |
| ▸ | PRKDC | P78527 | 10/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.48 |
| ▸ | ATR | Q13535 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL257265 | 0.90 | ATM (0.78) | ATMPRKDCKCNH2ATR | |
| SCHEMBL257264 | 0.86 | ATM (0.76) | ATMPRKDCKCNH2 | |
| SCHEMBL166632 | 0.86 | ATM (0.76) | ATMPRKDCKCNH2ATR | |
| SCHEMBL167830 | 0.85 | PRKDC (0.75) | ATMPRKDCKCNH2ATR | |
| SCHEMBL20031059 | 0.85 | PRKDC (0.77) | ATMPRKDC | |
| SCHEMBL29614884 | 0.85 | ATM (1.00) | ATMPRKDCKCNH2ATR | |
| SCHEMBL256590 | 0.85 | ATM (0.78) | ATMPRKDCKCNH2 | |
| SCHEMBL257266 | 0.85 | ATM (1.00) | ATMPRKDCKCNH2ATR | |
| SCHEMBL10059170 | 0.83 | PRKDC (0.73) | ATMPRKDCKCNH2 | |
| SCHEMBL256588 | 0.82 | PRKDC (1.00) | ATMPRKDCKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012028233-A1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | MERCK PATENT GMBH (DE) | 2012-03-08 | — | — | WO | disclosed |