Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 7/20 | 0.76 |
| ▸ | PRKDC | P78527 | 11/20 | 0.72 |
| ▸ | MTOR | P42345 | 5/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.46 |
| ▸ | PIK3C2A | O00443 | 2/20 | 0.46 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.46 |
| ▸ | LTK | P29376 | 1/20 | 0.46 |
| ▸ | CDK7 | P50613 | 1/20 | 0.46 |
| ▸ | NEK2 | P51955 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL257265 | 0.88 | ATM (0.78) | ATMPRKDCMTORPIK3CAPIK3CD | |
| SCHEMBL257264 | 0.88 | ATM (0.76) | ATMPRKDCMTORPIK3CAPIK3CD | |
| SCHEMBL20031059 | 0.87 | PRKDC (0.77) | ATMPRKDC | |
| SCHEMBL256590 | 0.87 | ATM (0.78) | ATMPRKDCMTORKCNH2 | |
| SCHEMBL257266 | 0.87 | ATM (1.00) | ATMPRKDCMTORPIK3CAPIK3CD | |
| SCHEMBL29614884 | 0.87 | ATM (1.00) | ATMPRKDCMTORPIK3CAPIK3CD | |
| SCHEMBL10060792 | 0.86 | ATM (0.74) | ATMPRKDCATRKCNH2 | |
| SCHEMBL167830 | 0.85 | PRKDC (0.75) | ATMPRKDCMTORPIK3CAPIK3CD | |
| SCHEMBL10059170 | 0.84 | PRKDC (0.73) | ATMPRKDCMTORPIK3CAPIK3CD | |
| SCHEMBL256588 | 0.83 | PRKDC (1.00) | ATMPRKDCMTORPIK3CAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170166567-A1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2017-06-15 | — | — | US | disclosed |
| US-20170166567-A1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2017-06-15 | — | — | US | disclosed |
| US-20170166567-A1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2017-06-15 | — | — | US | disclosed |
| US-9598408-B2 | Imidazo[4,5-C]quinolines as DNA-PK inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2017-03-21 | — | — | US | disclosed |
| US-9598408-B2 | Imidazo[4,5-C]quinolines as DNA-PK inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2017-03-21 | — | — | US | disclosed |
| US-9598408-B2 | Imidazo[4,5-C]quinolines as DNA-PK inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2017-03-21 | — | — | US | disclosed |
| US-20150203491-A1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2015-07-23 | — | — | US | disclosed |
| US-20150203491-A1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2015-07-23 | — | — | US | disclosed |
| US-20150203491-A1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2015-07-23 | — | — | US | disclosed |
| US-9000153-B2 | Imidazo[4,5-c]quinolines as DNA-PK inhibitors | MERCK PATENT GMBH (DE) | 2015-04-07 | — | — | US | disclosed |
| US-9000153-B2 | Imidazo[4,5-c]quinolines as DNA-PK inhibitors | MERCK PATENT GMBH (DE) | 2015-04-07 | — | — | US | disclosed |
| US-9000153-B2 | Imidazo[4,5-c]quinolines as DNA-PK inhibitors | MERCK PATENT GMBH (DE) | 2015-04-07 | — | — | US | disclosed |
| EP-2609082-B1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | MERCK PATENT GMBH (DE) | 2015-02-18 | — | — | EP | disclosed |
| EP-2609082-B1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | MERCK PATENT GMBH (DE) | 2015-02-18 | — | — | EP | disclosed |
| US-20130172337-A1 | Imidazo[4,5-c]quinolines as DNA-PK inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-07-04 | — | — | US | disclosed |
| US-20130172337-A1 | Imidazo[4,5-c]quinolines as DNA-PK inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-07-04 | — | — | US | disclosed |
| US-20130172337-A1 | Imidazo[4,5-c]quinolines as DNA-PK inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-07-04 | — | — | US | disclosed |
| EP-2609082-A1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | Merck Patent GmbH (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012028233-A1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | MERCK PATENT GMBH (DE) | 2012-03-08 | — | — | WO | disclosed |
| WO-2012028233-A1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | MERCK PATENT GMBH (DE) | 2012-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170166567-A1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | CHEK1, CHEK2, TTK | ATM 7/4885PRKDC 170/4885MTOR 285/4885 |
| US-20130172337-A1 | Imidazo[4,5-c]quinolines as DNA-PK inhibitors | CHEK1, CHEK2, TTK | ATM 7/4885PRKDC 170/4885MTOR 285/4885 |
| US-20150203491-A1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | CHEK1, CHEK2, TTK | ATM 7/4885PRKDC 170/4885MTOR 285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.