Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.74 |
| ▸ | LMNA | P02545 | 5/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.74 |
| ▸ | SHBG | P04278 | 3/20 | 0.74 |
| ▸ | SERPINA6 | P08185 | 3/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | TSHR | P16473 | 2/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.74 |
| ▸ | G6PD | P11413 | 2/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.74 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.74 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.74 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.74 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.74 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5154339 | 1.00 | GPBAR1 (0.74) | GPBAR1LMNACYP3A4SHBGSERPINA6 | |
| SCHEMBL3115963 | 1.00 | GPBAR1 (0.74) | GPBAR1LMNACYP3A4SHBGSERPINA6 | |
| SCHEMBL19750432 | 1.00 | GPBAR1 (0.74) | GPBAR1LMNACYP3A4SHBGSERPINA6 | |
| SCHEMBL19253221 | 1.00 | GPBAR1 (0.74) | GPBAR1LMNACYP3A4SHBGSERPINA6 | |
| SCHEMBL5173849 | 1.00 | GPBAR1 (0.74) | GPBAR1LMNACYP3A4SHBGSERPINA6 | |
| SCHEMBL13302861 | 1.00 | GPBAR1 (0.74) | GPBAR1LMNACYP3A4SHBGSERPINA6 | |
| SCHEMBL3115971 | 1.00 | GPBAR1 (0.74) | GPBAR1LMNACYP3A4SHBGSERPINA6 | |
| SCHEMBL1864977 | 1.00 | GPBAR1 (0.74) | GPBAR1LMNACYP3A4SHBGSERPINA6 | |
| Androsterone SCHEMBL23031469 | 0.85 | G6PD (1.00) | GPBAR1LMNACYP3A4SHBGSERPINA6 | |
| Androsterone SCHEMBL12811704 | 0.85 | G6PD (1.00) | GPBAR1LMNACYP3A4SHBGSERPINA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012021133-A1 | SYNTHETIC BILE ACID COMPOSITIONS AND METHODS | KYTHERA BIOPHARMACEUTICALS, INC. (US) | 2012-02-16 | — | — | WO | disclosed |