G6PD

Glucose-6-phosphate 1-dehydrogenase · P11413 · G6PD on Sugi Atlas →

52,767 patent compounds predicted against G6PD, 36,741 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL350388	1.00	11/20
SCHEMBL350389	1.00	11/20
Alfadolone (SCHEMBL57673)	1.00	9/20
Eltanolone (SCHEMBL56664)	1.00	7/20
Brexanolone (SCHEMBL56665)	1.00	7/20
Androsterone (SCHEMBL136325)	0.90	6/20
Androsterone (SCHEMBL235686)	0.90	6/20
SCHEMBL144878	0.65	6/20
Alfaxalone (SCHEMBL57756)	1.00	5/20
Etiocholanolone (SCHEMBL148334)	1.00	5/20
Androsterone (SCHEMBL200590)	1.00	5/20
Androsterone (SCHEMBL269981)	1.00	5/20
Androsterone (SCHEMBL269982)	1.00	5/20
Epiandrosterone (SCHEMBL295167)	1.00	5/20
Alfaxalone (SCHEMBL350372)	1.00	5/20
SCHEMBL332916	0.65	5/20
SCHEMBL191774	0.44	5/20
SCHEMBL50008	1.00	4/20
Tetrahydrocortisone (SCHEMBL193711)	0.79	4/20
Tetrahydrocortisone (SCHEMBL320596)	0.74	4/20

Clinical trials — most relevant to G6PD by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Efficacy and Safety of a Single Low-dose Primaquine for the Clearance of Gametocytes	PHASE4	COMPLETED
G6PD Assessment Before Primaquine for Radical Treatment of Vivax Malaria	PHASE4	COMPLETED
Short Course Radical Cure of P. Vivax Malaria in Nepal	PHASE4	COMPLETED
Lapdap and Coartemether for Uncomplicated Malaria	PHASE3	COMPLETED
Eight Week Primaquine Regimen for the Treatment of Vivax Malaria	PHASE3	COMPLETED
Pyronaridine Artesunate (3:1) in Children and Adults With Acute Plasmodium Vivax Malaria	PHASE3	COMPLETED
Safety and Efficacy of Different Regimens of Primaquine on Vivax Malaria Treatment in G6PD Deficient Patients	PHASE2	COMPLETED
Evaluation of Weekly Tafenoquine	PHASE2	COMPLETED
The Nitrite and Coronary Flow Study	PHASE1/PHASE2	COMPLETED
Long-Term Safety Study of Tafenoquine	PHASE2	COMPLETED
Experimental Malaria Infection of Healthy Malaria-Naive Adults by Mosquito Bite With the Genetically Modified Plasmodium Falciparum NF54/iGP3 GAP	PHASE1	NOT_YET_RECRUITING
Genetic Variability in CYP2D6 in U.S Active Duty Population	PHASE1	COMPLETED
Pharmacokinetic and in Vitro Transmission Blocking Activities Study of Primaquine Compare to Methylene Blue in Healthy Volunteer Both G6PD Normal and G6PD Deficiency	PHASE1	COMPLETED
Pharmacokinetic Study of Primaquine and Chloroquine in Healthy Subjects	PHASE1	COMPLETED
G6PD (Glucose-6-phosphate Dehydrogenase) Study to Evaluate Hemolysis Potential of TFQ (Tafenoquine)	PHASE1	COMPLETED
Effect of G6PD Deficiency on Red Blood Cell Storage	nan	COMPLETED
Validation of Diagnostics to Identify Glucose-6-phosphate Dehydrogenase Activity in the US	nan	COMPLETED
IMPROV (Improving the Radical Cure of Vivax Malaria)	nan	COMPLETED
Evaluation of a Diagnostic to Identify Glucose-6-phosphate Dehydrogenase (G6PD) Deficiency in Brazil	nan	COMPLETED
Evaluation of Different G6PD Testing Platforms	nan	COMPLETED
Serological Screen and Treat Trial for Plasmodium Vivax	nan	UNKNOWN
Screening of Coexistence Between Sickle Cell Anaemia and G6PD Deficiency	nan	NOT_YET_RECRUITING
Validation of New G6PD Point of Care Tests Against Gold Standard Quantitative	nan	COMPLETED
Energy Cost of Posture Maintenance, Ethnic Differences and the Influence of Metabolic State	nan	COMPLETED
Comparing G6PD Tests Using Capillary Blood Versus Venous Blood	nan	COMPLETED
Acute and Long-term Health Effects of Various Carbohydrates on Blood Glucose Management in Humans	nan	COMPLETED
Comparative Evaluation of the FINDER Instrument and FINDER G6PD Cartridge in Adults and Neonates	nan	COMPLETED
Effects of Lentinula Edodes Bars on Dyslipidemia and Oxidative Stress in Cholesterol Individuals: Randomized Study	nan	COMPLETED
Operational Feasibility of Appropriate Radical Cure of Plasmodium Vivax With Tafenoquine or Primaquine After Quantitative G6PD Testing in Brazil	nan	UNKNOWN
Short Course Primaquine for the Radical Cure of P. Vivax Malaria - Indonesia	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a G6PD binder may also engage these)

Protein	Name	Similarity
O55044	—	1.000	O55044 →
Q29492	—	1.000	Q29492 →
P05370	—	1.000	P05370 →
P12646	—	1.000	P12646 →
Q00612	—	1.000	Q00612 →
P54996	—	1.000	P54996 →
Q27464	—	1.000	Q27464 →
P97324	—	1.000	P97324 →
P41571	—	1.000	P41571 →
Q27638	—	1.000	Q27638 →
P48826	—	0.999	P48826 →
Q7YS37	—	0.996	Q7YS37 →
P11410	—	0.996	P11410 →
Q557D2	—	0.995	Q557D2 →
Q9LK23	—	0.994	Q9LK23 →
P37830	—	0.994	P37830 →
Q9FJI5	—	0.993	Q9FJI5 →
P48828	—	0.992	P48828 →
Q42919	—	0.991	Q42919 →
P11412	—	0.991	P11412 →
P41764	—	0.990	P41764 →
O00091	—	0.989	O00091 →
Q43727	—	0.988	Q43727 →
Q9FY99	—	0.987	Q9FY99 →
P0AC53	—	0.986	P0AC53 →
Q5E9R3	—	0.986	Q5E9R3 →
O94609	—	0.986	O94609 →
Q43839	—	0.986	Q43839 →
Q8XCJ6	—	0.986	Q8XCJ6 →
Q9NZN3	—	0.985	Q9NZN3 →