Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 5/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.53 |
| ▸ | VDR | P11473 | 1/20 | 0.53 |
| ▸ | NPC1L1 | Q9UHC9 | 4/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
| ▸ | POLA1 | P09884 | 1/20 | 0.44 |
| ▸ | TOP2A | P11388 | 1/20 | 0.44 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12947554 | 0.95 | GPBAR1 (0.59) | GPBAR1CYP2C9HIF1AVDRUSP2 | |
| SCHEMBL10060838 | 0.95 | GPBAR1 (0.59) | GPBAR1CYP2C9HIF1AVDRUSP2 | |
| SCHEMBL11517446 | 0.95 | GPBAR1 (0.59) | GPBAR1CYP2C9HIF1AVDRUSP2 | |
| SCHEMBL11967233 | 0.95 | GPBAR1 (0.59) | GPBAR1CYP2C9HIF1AVDRUSP2 | |
| SCHEMBL15133019 | 0.95 | GPBAR1 (0.59) | GPBAR1CYP2C9HIF1AVDRUSP2 | |
| SCHEMBL12917607 | 0.95 | GPBAR1 (0.59) | GPBAR1CYP2C9HIF1AVDRUSP2 | |
| SCHEMBL970323 | 0.95 | GPBAR1 (0.59) | GPBAR1CYP2C9HIF1AVDRUSP2 | |
| SCHEMBL24571894 | 0.92 | GPBAR1 (0.45) | GPBAR1CYP2C9HIF1AVDRNPC1L1 | |
| SCHEMBL967481 | 0.88 | POLA1 (0.58) | GPBAR1HIF1AVDRUSP2MEN1 | |
| SCHEMBL17656424 | 0.88 | POLA1 (0.58) | GPBAR1HIF1AVDRUSP2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130029958-A1 | SYNTHETIC BILE ACID COMPOSITIONS AND METHODS | KYTHERA BIOPHARMACEUTICALS, INC. | 2013-01-31 | — | — | US | disclosed |
| US-20120302525-A1 | SYNTHETIC BILE ACID COMPOSITIONS AND METHODS | KYTHERA BIOPHARMACEUTICALS, INC. | 2012-11-29 | — | — | US | disclosed |
| US-20120238537-A1 | SYNTHETIC BILE ACID COMPOSITIONS AND METHODS | KYTHERA BIOPHARMACEUTICALS, INC. | 2012-09-20 | — | — | US | disclosed |
| US-8242294-B2 | Synthetic bile acid compositions and methods | KYTHERA BIOPHARMACEUTICALS, INC. (US) | 2012-08-14 | — | — | US | disclosed |
| WO-2012021133-A1 | SYNTHETIC BILE ACID COMPOSITIONS AND METHODS | KYTHERA BIOPHARMACEUTICALS, INC. (US) | 2012-02-16 | — | — | WO | disclosed |
| EP-2407475-A2 | Synthetic Bile Acid Composition, Method, and Preparation | Kythera Biopharmaceuticals, Inc. (US) | 2012-01-18 | — | — | EP | disclosed |
| US-20100160276-A1 | SYNTHETIC BILE ACID COMPOSITIONS AND METHODS | KYTHERA BIOPHARMACEUTICALS, INC. | 2010-06-24 | — | — | US | disclosed |
| US-20080318870-A1 | SYNTHETIC BILE ACID COMPOSITIONS AND METHODS | KYTHERA BIOPHARMACEUTICALS, INC. | 2008-12-25 | — | — | US | disclosed |
| WO-2008157635-A2 | SYNTHETIC BILE ACID COMPOSITION, METHOD, AND PREPARATION | KYTHERA BIOPHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120302525-A1 | SYNTHETIC BILE ACID COMPOSITIONS AND METHODS | NR1H4, CYP27A1, CYP7A1 | GPBAR1 6/4885CYP2C9 92/4885HIF1A 4334/4885 |
| US-20120238537-A1 | SYNTHETIC BILE ACID COMPOSITIONS AND METHODS | NR1H4, CYP27A1, CYP7A1 | GPBAR1 6/4885CYP2C9 92/4885HIF1A 4334/4885 |
| US-20100160276-A1 | SYNTHETIC BILE ACID COMPOSITIONS AND METHODS | NR1H4, CYP27A1, CYP7A1 | GPBAR1 6/4885CYP2C9 92/4885HIF1A 4334/4885 |
| US-20080318870-A1 | SYNTHETIC BILE ACID COMPOSITIONS AND METHODS | NR1H4, CYP27A1, CYP7A1 | GPBAR1 6/4885CYP2C9 92/4885HIF1A 4334/4885 |
| US-20130029958-A1 | SYNTHETIC BILE ACID COMPOSITIONS AND METHODS | NR1H4, CYP27A1, CYP7A1 | GPBAR1 6/4885CYP2C9 92/4885HIF1A 4334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.