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Sugi Predict / Targets / CYP27A1

CYP27A1

Sterol 26-hydroxylase, mitochondrial · Q02318 · CYP27A1 on Sugi Atlas →

1,445 patent compounds predicted against CYP27A1, 830 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL9446419 SCHEMBL9446419 0.46 4/20
SCHEMBL13822557 SCHEMBL13822557 0.45 4/20
SCHEMBL229052 SCHEMBL229052 0.79 3/20
SCHEMBL7245357 SCHEMBL7245357 0.76 3/20
SCHEMBL630276 SCHEMBL630276 0.70 3/20
SCHEMBL14165623 SCHEMBL14165623 0.66 3/20
SCHEMBL14159089 SCHEMBL14159089 0.65 3/20
SCHEMBL4623145 SCHEMBL4623145 0.65 3/20
SCHEMBL4621871 SCHEMBL4621871 0.65 3/20
SCHEMBL4853888 SCHEMBL4853888 0.65 3/20
SCHEMBL6827615 SCHEMBL6827615 0.64 3/20
SCHEMBL8159828 SCHEMBL8159828 0.64 3/20
SCHEMBL7590283 SCHEMBL7590283 0.64 3/20
SCHEMBL8012038 SCHEMBL8012038 0.64 3/20
SCHEMBL8938852 SCHEMBL8938852 0.63 3/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL10341505) 0.62 3/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL4622195) 0.62 3/20
SCHEMBL6822323 SCHEMBL6822323 0.62 3/20
SCHEMBL4621209 SCHEMBL4621209 0.62 3/20
SCHEMBL8203668 SCHEMBL8203668 0.61 3/20

Clinical trials — most relevant to CYP27A1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Evaluation of the Effects of Calcitriol's in the Neurological Symptoms of Friedreich's Ataxia Patients PHASE4COMPLETED
The Role of CYP8B1 Polymorphisms in Modulating the Biochemical Pathways Affected by SGLT2 Inhibitors in T2DM and Obesity PHASE4COMPLETED
Effect of Silymarin in Rheumatoid Arthritis Patients Treated With Methotrexate PHASE4NOT_YET_RECRUITING
Effect of Single High Dose of Cholecalciferol on Serum Metabolites of Vitamin D PHASE4COMPLETED
Effect of Vitamin D Supplementation on Exercise Adaptations in Patients on Statin Therapy PHASE3COMPLETED
Theca Cell Function in Adolescents With Polycystic Ovary Syndrome (PCOS) PHASE3COMPLETED
Smith-Lemli-Opitz Syndrome and Cholic Acid PHASE1/PHASE2COMPLETED
Cholic Acid for Hepatic Steatosis in Lipodystrophy PHASE2COMPLETED
Biomarker Validation for Niemann-Pick Disease, Type C: Safety and Efficacy of N-Acetyl Cysteine PHASE1/PHASE2COMPLETED
Cholecalciferol on Depressive Symptoms in Type 2 Diabetes Mellitus Patients PHASE2UNKNOWN
The Prevalence of Vitamin D Deficiency and Effects of Vitamin D Supplementation in HIV-1 Infected Patients PHASE2UNKNOWN
Efavirenz for Patients With Alzheimer's Disease PHASE1COMPLETED
The Antibiotic Rifampin to Reduce High Levels of Blood and Urine Calcium in IIH PHASE1UNKNOWN
A Pilot Study to Examine the Effects of Vitamin D Supplementation on Mitochondrial Bioenergetics in Older Adults EARLY_PHASE1COMPLETED
Mutation Analysis of 17α-Hydroxylase nanUNKNOWN
Gene Expression, Metabolomic, Microbiome, and Calcium Metabolism in Response to Varied Vitamin D Dosages nanCOMPLETED
Cholestanol in Humans nanWITHDRAWN
Polycystic Ovary Syndrome in Type 1 Diabetes nanNOT_YET_RECRUITING
Study of Smith-Lemli-Opitz Syndrome nanCOMPLETED
Cholesterol and CYP3A4/5 Metabolism Across Pregnancy and Postpartum nanCOMPLETED
Normal Pressure Hydrocephalus Biomarkers Investigation nanUNKNOWN
Replacement of Vitamin D in Patients With Active Tuberculosis nanCOMPLETED
Predictors of Outcome of Pediatric Renal Transplantation nanNOT_YET_RECRUITING
Drug Metabolizing Enzyme and Transporter Function in Chronic Kidney Disease nanCOMPLETED
Hypercalcemia After Paraffin Oil Injection nanRECRUITING
Osmotic Fragility in Red Blood Cells of Pediatric Patients With Cholestatic Liver Disease nanACTIVE_NOT_RECRUITING
Exploring the Relationship Between Androgen Metabolism, Metabolic Disease and Skeletal Muscle Energy Balance in Men nanUNKNOWN
Biomarkers in the Etiology of Idiopathic Intracranial Hypertension nanUNKNOWN
Final Height in Patients With CAH nanUNKNOWN
Cholecalciferol for Vitamin D in Adult Cystic Fibrosis (CF) Patients nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a CYP27A1 binder may also engage these)

ProteinNameSimilarity
P17177 — 0.998 P17177 →
P17178 — 0.998 P17178 →
Q9DBG1 — 0.997 Q9DBG1 →
P97720 — 0.995 P97720 →
Q92104 — 0.987 Q92104 →
P10612 — 0.984 P10612 →
P79153 — 0.983 P79153 →
O46515 — 0.983 O46515 →
P15393 — 0.983 P15393 →
CYP11A1 Cholesterol side-chain cleavage enzyme, mitochondrial 0.983 landscape →
Q28827 — 0.983 Q28827 →
P00189 — 0.983 P00189 →
P15539 — 0.981 P15539 →
Q9QZ82 — 0.979 Q9QZ82 →
P79202 — 0.978 P79202 →
Q64408 — 0.978 Q64408 →
P30099 — 0.977 P30099 →
O35084 — 0.977 O35084 →
P14137 — 0.976 P14137 →
P30100 — 0.976 P30100 →
Q64658 — 0.975 Q64658 →
Q2XV99 — 0.974 Q2XV99 →
Q9EPT4 — 0.974 Q9EPT4 →
CYP27B1 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial 0.972 landscape →
CYP8B1 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase 0.971 landscape →
O35132 — 0.970 O35132 →
O35074 — 0.969 O35074 →
Q07217 — 0.968 Q07217 →
P14581 — 0.967 P14581 →
Q62969 — 0.966 Q62969 →