Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 3/20 | 0.46 |
| ▸ | PDE8A | O60658 | 3/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.45 |
| ▸ | PDE2A | O00408 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 9/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.40 |
| ▸ | PNP | P00491 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19157558 | 0.89 | PDE8A (0.45) | CDK1PDE8APDE4DPDE2AKCNH2 | |
| SCHEMBL13981871 | 0.87 | CDK1 (0.49) | CDK1PDE8APDE4DPDE2AKCNH2 | |
| SCHEMBL20059153 | 0.84 | CDK1 (0.46) | CDK1PDE8APDE4DPDE2AKCNH2 | |
| SCHEMBL13770668 | 0.82 | ADORA2A (0.56) | PDE4DPDE2AADORA2AADORA1LMNA | |
| SCHEMBL24835574 | 0.78 | CDK1 (0.59) | CDK1PDE8APDE4DPDE2AKCNH2 | |
| SCHEMBL10048814 | 0.78 | BLM (0.38) | CDK1CDK2CCNB1CCNE1PDE3A | |
| SCHEMBL15959268 | 0.77 | PDE8A (0.48) | CDK1PDE8APDE4DPDE2AKCNH2 | |
| SCHEMBL24081983 | 0.77 | CDK2 (0.40) | CDK1CDK2CCNB1CCNE1 | |
| SCHEMBL10062071 | 0.76 | PDE8A (0.49) | CDK1PDE8APDE4DPDE2AKCNH2 | |
| SCHEMBL14457638 | 0.76 | PDE8A (0.47) | CDK1PDE8APDE4DPDE2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8227433-B2 | Use of inhibitors and antisense oligonucleotides of BTK for treating proliferative mastocytosis | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2012-07-24 | — | — | US | disclosed |
| EP-2404926-A1 | Preparation of 2-chloro-9-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-adenine | ScinoPharm Taiwan, Ltd. (TW) | 2012-01-11 | — | — | EP | disclosed |
| US-20100216733-A1 | Use of inhibitors and antisense oligonucleotides of btk for treating proliferative mastocytosis | UNIVERSITÉ PARIS-SACLAY (FR) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216733-A1 | Use of inhibitors and antisense oligonucleotides of btk for treating proliferative mastocytosis | BTK, LYN, SYK | CDK1 253/4885PDE8A 2160/4885PDE4D 688/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.