Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 5/20 | 1.00 |
| ▸ | IKBKB | O14920 | 5/20 | 1.00 |
| ▸ | PRKAG1 | P54619 | 5/20 | 1.00 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 1.00 |
| ▸ | NEK1 | Q96PY6 | 5/20 | 1.00 |
| ▸ | PRKAB1 | Q9Y478 | 5/20 | 1.00 |
| ▸ | RAF1 | P04049 | 3/20 | 1.00 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 1.00 |
| ▸ | AKT1 | P31749 | 3/20 | 1.00 |
| ▸ | AKT2 | P31751 | 3/20 | 1.00 |
| ▸ | KDR | P35968 | 3/20 | 1.00 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 1.00 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 1.00 |
| ▸ | PRDX1 | Q06830 | 1/20 | 0.68 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 7/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.62 |
| ▸ | NPC1 | O15118 | 5/20 | 0.62 |
| ▸ | RAB9A | P51151 | 5/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31070046 | 1.00 | MAPK1 (1.00) | MAPK1IKBKBPRKAG1PRKAA1NEK1 | |
| SCHEMBL29794510 | 0.81 | IKBKB (1.00) | MAPK1IKBKBPRKAG1PRKAA1NEK1 | |
| SCHEMBL21460535 | 0.81 | IKBKB (1.00) | MAPK1IKBKBPRKAG1PRKAA1NEK1 | |
| SCHEMBL12948680 | 0.81 | MAPK1 (0.70) | MAPK1IKBKBPRKAG1PRKAA1NEK1 | |
| SCHEMBL8106620 | 0.81 | IKBKB (1.00) | MAPK1IKBKBPRKAG1PRKAA1NEK1 | |
| SCHEMBL21460534 | 0.81 | IKBKB (1.00) | MAPK1IKBKBPRKAG1PRKAA1NEK1 | |
| SCHEMBL17899536 | 0.79 | IKBKB (0.68) | MAPK1IKBKBPRKAG1PRKAA1NEK1 | |
| SCHEMBL8120726 | 0.77 | IKBKB (1.00) | MAPK1IKBKBPRKAG1PRKAA1NEK1 | |
| SCHEMBL17899485 | 0.77 | MAPT (1.00) | MAPK1IKBKBPRKAG1PRKAA1NEK1 | |
| SCHEMBL29437157 | 0.77 | IKBKB (1.00) | MAPK1IKBKBPRKAG1PRKAA1NEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012021692-A1 | CURCUMIN ANALOGS AND METHODS OF USE THEREOF | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2012-02-16 | — | — | WO | disclosed |