Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 7/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 6/20 | 1.00 |
| ▸ | RAF1 | P04049 | 4/20 | 1.00 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 1.00 |
| ▸ | AKT1 | P31749 | 4/20 | 1.00 |
| ▸ | AKT2 | P31751 | 4/20 | 1.00 |
| ▸ | KDR | P35968 | 4/20 | 1.00 |
| ▸ | PRKAG1 | P54619 | 4/20 | 1.00 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 1.00 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 1.00 |
| ▸ | NEK1 | Q96PY6 | 4/20 | 1.00 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 1.00 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 1.00 |
| ▸ | MAPK14 | Q16539 | 2/20 | 1.00 |
| ▸ | PRDX1 | Q06830 | 1/20 | 1.00 |
| ▸ | NPC1 | O15118 | 5/20 | 0.64 |
| ▸ | RAB9A | P51151 | 5/20 | 0.64 |
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 4/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8106620 | 1.00 | IKBKB (1.00) | IKBKBMAPK1RAF1RPS6KB1AKT1 | |
| SCHEMBL21460535 | 1.00 | IKBKB (1.00) | IKBKBMAPK1RAF1RPS6KB1AKT1 | |
| SCHEMBL21460534 | 1.00 | IKBKB (1.00) | IKBKBMAPK1RAF1RPS6KB1AKT1 | |
| SCHEMBL12948680 | 0.82 | MAPK1 (0.70) | IKBKBMAPK1RAF1RPS6KB1AKT1 | |
| SCHEMBL31070046 | 0.81 | MAPK1 (1.00) | IKBKBMAPK1RAF1RPS6KB1AKT1 | |
| SCHEMBL10062873 | 0.81 | MAPK1 (1.00) | IKBKBMAPK1RAF1RPS6KB1AKT1 | |
| SCHEMBL17899536 | 0.81 | IKBKB (0.68) | IKBKBMAPK1RAF1RPS6KB1AKT1 | |
| SCHEMBL28214806 | 0.79 | MAPK1 (0.66) | IKBKBMAPK1RAF1RPS6KB1AKT1 | |
| SCHEMBL3006214 | 0.79 | MAPK1 (0.64) | IKBKBMAPK1RAF1RPS6KB1AKT1 | |
| SCHEMBL17899485 | 0.78 | MAPT (1.00) | IKBKBMAPK1RAF1RPS6KB1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240398799-A1 | COMPOSITIONS AND METHODS FOR GENERATING SYNTHETIC LETHALITY IN TUMORS | ENGINE BIOSCIENCES PTE. LTD. (SG) | 2024-12-05 | — | — | US | disclosed |
| EP-4388137-A1 | COMPOSITIONS AND METHODS FOR GENERATING SYNTHETIC LETHALITY IN TUMORS | Engine Biosciences Pte. Ltd. (SG) | 2024-06-26 | — | — | EP | disclosed |
| US-20230078425-A1 | COMPOSITIONS AND METHODS FOR GENERATING SYNTHETIC LETHALITY IN TUMORS | ENGINE BIOSCIENCES PTE. LTD. (SG) | 2023-03-16 | — | — | US | disclosed |
| WO-2023022659-A1 | COMPOSITIONS AND METHODS FOR GENERATING SYNTHETIC LETHALITY IN TUMORS | ENGINE BIOSCIENCES PTE. LTD. (SG) | 2023-02-23 | — | — | WO | disclosed |
| CN-114787359-A | Method for producing peptide containing unnatural amino acid | 中外制药株式会社 | 2022-07-22 | — | — | CN | disclosed |