⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1004944 | 1.00 | GPR84 (0.45) | — | |
| SCHEMBL1006930 | 1.00 | GPR84 (0.45) | — | |
| SCHEMBL329265 | 1.00 | — | — | |
| SCHEMBL3028793 | 1.00 | GPR84 (0.45) | — | |
| SCHEMBL1007247 | 1.00 | GPR84 (0.45) | — | |
| SCHEMBL1008160 | 1.00 | GPR84 (0.45) | — | |
| SCHEMBL1007034 | 1.00 | GPR84 (0.45) | — | |
| SCHEMBL1006956 | 1.00 | GPR84 (0.45) | — | |
| SCHEMBL1007009 | 1.00 | GPR84 (0.45) | — | |
| SCHEMBL1006246 | 1.00 | GPR84 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105611920-B | Preparation of hydroxy-diphenylmethane derivatives | 泰拉科斯萨普有限责任公司 | 2021-07-16 | — | — | CN | disclosed |
| EP-3055281-B1 | PREPARATION OF HYDROXY-BENZYLBENZENE DERIVATIVES | THERACOS SUB LLC (US) | 2020-01-08 | — | — | EP | disclosed |
| US-10093616-B2 | Preparation of hydroxy-benzylbenzene derivatives | THERACOS SUB, LLC (US) | 2018-10-09 | — | — | US | disclosed |
| US-9725478-B2 | Process for the preparation of benzylbenzene SGLT2 inhibitors | THERACOS SUB, LLC (US) | 2017-08-08 | — | — | US | disclosed |
| US-20160355471-A1 | PREPARATION OF HYDROXY-BENZYLBENZENE DERIVATIVES | THERACOSBIO, LLC | 2016-12-08 | — | — | US | disclosed |
| US-9464043-B2 | Preparation of hydroxy-benzylbenzene derivatives | THERACOS SUB, LLC (US) | 2016-10-11 | — | — | US | disclosed |
| EP-3055281-A1 | PREPARATION OF HYDROXY-BENZYLBENZENE DERIVATIVES | Theracos Sub, LLC (US) | 2016-08-17 | — | — | EP | disclosed |
| US-20160207952-A1 | PROCESS FOR THE PREPARATION OF BENZYLBENZENE SGLT2 INHIBITORS | THERACOSBIO, LLC | 2016-07-21 | — | — | US | disclosed |
| US-9231278-B2 | Electrolyte solution for magnesium battery and magnesium battery containing this electrolyte solution | NATIONAL UNIVERSITY CORPORATION NAGOYA INSTITUTE OF TECHNOLOGY (JP) | 2016-01-05 | — | — | US | disclosed |
| US-9193751-B2 | Process for the preparation of benzylbenzene SGLT2 inhibitors | THERACOS, INC. (US) | 2015-11-24 | — | — | US | disclosed |
| EP-0382185-B1 | Carbostyril derivatives | OTSUKA PHARMA CO LTD (JP) | 1994-06-15 | — | — | EP | disclosed |
| WO-1994001113-A1 | OXYTOCIN ANTAGONIST | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1994-01-20 | — | — | WO | disclosed |
| US-5225402-A | Vasopressin antagonist, vasodilation, hypotensive, diuretics and anticoagulants | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-07-06 | — | — | US | disclosed |
| US-5219852-A | Hypoglycemic agents, treatment of diabetes and obesity | DR. KARL THOMAE GMBH (DE) | 1993-06-15 | — | — | US | disclosed |
| US-5053548-A | Containing hydroxy substituents; nervous system disorders | OTSUKA PHARMACEUTICAL COMPANY, LTD. (JP) | 1991-10-01 | — | — | US | disclosed |
| EP-0239815-B1 | SUBSTITUTED THIAZOLES AND OXAZOLES, MEDICINES CONTAINING THESE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | Dr. Karl Thomae GmbH (DE) | 1991-07-24 | — | — | EP | disclosed |
| US-5026702-A | Enhances physical performance in animals, effective in lowering blood sugar, reducing body fat and lowering atherogenic lipoproteins | DR. KARL THOMAE, GMBH (DE) | 1991-06-25 | — | — | US | disclosed |
| EP-0382213-A2 | Biphenyl derivative, nerve cell degeneration repairing or protecting agent and process for preparing a phenyl derivative contained in the agent | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-08-16 | — | — | EP | disclosed |
| EP-0382185-A2 | Carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-08-16 | — | — | EP | disclosed |
| US-4886814-A | LOWER BLOOD SUGAR | DR. KARL THOMAS GMBH (DE) | 1989-12-12 | — | — | US | disclosed |