Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.50 |
| ▸ | OGFRL1 | Q5TC84 | 3/20 | 0.50 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | F12 | P00748 | 2/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2141647 | 0.94 | OPRM1 (0.54) | OPRM1OGFRL1OPRL1KMT2AMEN1 | |
| SCHEMBL2141136 | 0.86 | OPRM1 (0.54) | OPRM1OGFRL1OPRL1KMT2AMEN1 | |
| SCHEMBL2140032 | 0.85 | OPRM1 (0.54) | OPRM1OGFRL1OPRL1KMT2AMEN1 | |
| SCHEMBL2141981 | 0.82 | OPRM1 (0.49) | OPRM1OGFRL1OPRL1KMT2ATRPV1 | |
| SCHEMBL2139574 | 0.82 | OPRM1 (0.54) | OPRM1OGFRL1OPRL1KMT2AMEN1 | |
| SCHEMBL2140335 | 0.81 | OPRM1 (0.58) | OPRM1OGFRL1OPRL1KMT2AMEN1 | |
| SCHEMBL2141092 | 0.81 | OPRM1 (0.52) | OPRM1OGFRL1OPRL1KMT2ATRPV1 | |
| SCHEMBL2142688 | 0.80 | OPRM1 (0.54) | OPRM1OGFRL1OPRL1KMT2AMEN1 | |
| SCHEMBL2142957 | 0.80 | OPRM1 (0.52) | OPRM1OGFRL1OPRL1KMT2AMEN1 | |
| SCHEMBL2137582 | 0.80 | OPRM1 (0.52) | OPRM1OGFRL1OPRL1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1868600-B1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVES FOR USE IN THE TREATMENT OF SUBSTANCE DEPENDENCY | GRUENENTHAL GMBH (DE) | 2012-06-27 | — | — | EP | disclosed |