OPRM1

Mu-type opioid receptor · P35372 · OPRM1 on Sugi Atlas →

666,500 patent compounds predicted against OPRM1, 401,725 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL24579	0.82	15/20
Dezocine (SCHEMBL3072)	1.00	13/20
Butorphanol (SCHEMBL3749)	1.00	13/20
Lofentanil (SCHEMBL26429)	1.00	13/20
Dihydrocodeine (SCHEMBL24607)	0.77	12/20
Thebacon (SCHEMBL25766)	0.63	12/20
Nicomorphine (SCHEMBL26237)	0.60	12/20
Myrophine (SCHEMBL26043)	0.56	12/20
Hydrocodone (SCHEMBL2987)	1.00	11/20
Nalbuphine (SCHEMBL3766)	1.00	11/20
(R,R)-Tramadol (SCHEMBL7464)	1.00	11/20
Loperamide (SCHEMBL15048)	1.00	10/20
Meperidine (SCHEMBL25431)	1.00	10/20
Loperamide (SCHEMBL28530)	1.00	10/20
Ethoheptazine (SCHEMBL24581)	0.90	10/20
Fenspiride (SCHEMBL21016)	0.60	10/20
SCHEMBL1510	0.58	10/20
Propiram (SCHEMBL26193)	0.47	10/20
Fentanyl (SCHEMBL8804)	1.00	9/20
Buprenorphine (SCHEMBL15820)	1.00	9/20

Clinical trials — most relevant to OPRM1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Population Pharmacokinetics and Pharmacogenomics of Oral Oxycodone in Thai Pediatric Surgical Patients	PHASE4	UNKNOWN
OXY-1: The Pharmacogenetics of Oxycodone Analgesia in Postoperative Pain	PHASE4	COMPLETED
Population Pharmacokinetics and Pharmacogenomics of Oral Oxycodone in Pediatric Surgical Patients	PHASE4	ACTIVE_NOT_RECRUITING
OXY-2: The Pharmacogenetics of Oxycodone Analgesia in Human Experimental Pain Models	PHASE4	COMPLETED
Colonic Motor Patterns in Healthy Volunteers	PHASE4	COMPLETED
Targeted Naltrexone for Problem Drinkers	PHASE4	COMPLETED
Oliceridine in Patients With Acute Burn Injuries	PHASE4	COMPLETED
Prospective Study About Clinical and Pharmacogenetic Safety of Opioid Use for Chronic Pain	PHASE4	SUSPENDED
the Efficacy and Safety of Oliceridine Fumarate Injection for Acute Pain After Abdominal Surgery	PHASE4	NOT_YET_RECRUITING
Extended-release Naltrexone and Care Management for Alcohol Dependent Frequent Emergency Department Users	PHASE4	COMPLETED
A118G SNP and OPRM1 Gene Opioid-Mediated Effects in Humans	PHASE2	COMPLETED
Efficacy of Fentanyl Soaked Nasal Packs on Postoperative Pain in Nasal Surgeries.	PHASE2	NOT_YET_RECRUITING
Genetic Effects on Dopamine Response to an Opiate	PHASE2	COMPLETED
Acute and Short-term Effects of Cannabidiol Admin on Cue-induced Craving in Drug-abstinent Heroin Dependent Humans	PHASE2	COMPLETED
Safety, Tolerability, PK Profile, and Symptom Response of a 7-Day Dosing With 25 mg or 50 mg Daily of REL-1017 in MDD	PHASE2	COMPLETED
Acute and Short-term Effects of CBD on Cue-induced Craving in Drug-abstinent Heroin-dependent Humans	PHASE2	COMPLETED
Naltrexone for Individuals of East Asian Descent	PHASE2	COMPLETED
Study to Test the Safety and Efficacy of Cannabidiol as a Treatment Intervention for Opioid Relapse	PHASE1	COMPLETED
Sensitivity to Intravenous Nicotine: Genetic Moderators	PHASE1	COMPLETED
Title: Effect of Opioid Receptor Modulation on Alcohol Self-Administration and Neural Response to Alcohol Cues in Heavy Drinkers: Role of OPRM1 Gene Variation	PHASE1	COMPLETED
Pharmacokinetics of Intravenous and Intranasal Formulations of Naloxone in Healthy Volunteers.	PHASE1	COMPLETED
The Effect of Naltrexone on Alcohol Craving and on Brain Activity During Alcohol Infusion	EARLY_PHASE1	COMPLETED
OPRM1 A118G SNP, Alcohol Response, and Striatal Dopamine	nan	COMPLETED
Linking Epigenomics With Prescription Opioid Abuse and High Impact Musculoskeletal Pain	nan	COMPLETED
A Study of Genetic Variation Influencing Pain and Response to Opioid Medications	nan	WITHDRAWN
Precision Medicine Guided Treatment for Cancer Pain	nan	COMPLETED
Multicenter Perioperative Opioid Pharmacogenetic Study	nan	COMPLETED
Intermountain Healthcare's Enhanced Recovery Protocol for Colon Surgery With and Without Alvimopan Use	nan	COMPLETED
Effect of Intraperitoneal Bupivacaine with Dexmedotomidine or Fentanyl for Post-Operative Analgesia Following Laparoscopy in Pediatric Patients	nan	NOT_YET_RECRUITING
Patient Controlled Analgesia Pharmacogenetic Study	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a OPRM1 binder may also engage these)

Protein	Name	Similarity
Q5IS39	—	1.000	Q5IS39 →
Q95M54	—	1.000	Q95M54 →
P42866	—	1.000	P42866 →
Q95247	—	1.000	Q95247 →
Q5IS84	—	1.000	Q5IS84 →
P79350	—	1.000	P79350 →
P33535	—	1.000	P33535 →
Q9MYW9	—	0.994	Q9MYW9 →
P33534	—	0.991	P33534 →
P34975	—	0.988	P34975 →
P41144	—	0.987	P41144 →
OPRK1	Kappa-type opioid receptor	0.985	landscape →
Q2KIP6	—	0.980	Q2KIP6 →
P30680	—	0.968	P30680 →
P35377	—	0.967	P35377 →
P35370	—	0.965	P35370 →
P33533	—	0.963	P33533 →
P32300	—	0.962	P32300 →
P30875	—	0.962	P30875 →
Q49LX6	—	0.961	Q49LX6 →
SSTR2	Somatostatin receptor type 2	0.960	landscape →
P34994	—	0.959	P34994 →
P34993	—	0.956	P34993 →
NMBR	Neuromedin-B receptor	0.956	landscape →
P21729	—	0.955	P21729 →
OPRD1	Delta-type opioid receptor	0.955	landscape →
P24053	—	0.955	P24053 →
P47748	—	0.954	P47748 →
OPRL1	Nociceptin receptor	0.954	landscape →
B2ZI34	—	0.954	B2ZI34 →