Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 20/20 | 0.65 |
| ▸ | OGFRL1 | Q5TC84 | 12/20 | 0.65 |
| ▸ | OPRL1 | P41146 | 10/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2139927 | 0.94 | OPRM1 (0.66) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL2141380 | 0.90 | OPRM1 (0.71) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL2139659 | 0.89 | OPRM1 (0.57) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL2139636 | 0.85 | OPRM1 (0.71) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL2138564 | 0.85 | OPRM1 (0.71) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL2142158 | 0.85 | OPRM1 (0.73) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL2142164 | 0.84 | OPRM1 (0.75) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL2140017 | 0.84 | OPRM1 (0.62) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL2141802 | 0.84 | OPRM1 (0.71) | OPRM1OGFRL1OPRL1OPRD1OPRK1 | |
| SCHEMBL2142497 | 0.83 | OPRM1 (0.73) | OPRM1OGFRL1OPRL1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1868600-B1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVES FOR USE IN THE TREATMENT OF SUBSTANCE DEPENDENCY | GRUENENTHAL GMBH (DE) | 2012-06-27 | — | — | EP | disclosed |