Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 5/20 | 0.44 |
| ▸ | STK4 | Q13043 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 4/20 | 0.39 |
| ▸ | VRK2 | Q86Y07 | 2/20 | 0.39 |
| ▸ | VRK1 | Q99986 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.39 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.39 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 8/20 | 0.39 |
| ▸ | TAF1 | P21675 | 1/20 | 0.38 |
| ▸ | PLK2 | Q9NYY3 | 6/20 | 0.36 |
| ▸ | PLK3 | Q9H4B4 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10065442 | 0.89 | RPS6KA3 (0.55) | RPS6KA3STK4BRD4VRK2VRK1 | |
| SCHEMBL10065443 | 0.86 | PLK1 (0.52) | RPS6KA3BRD4CSNK1A1RPS6KA2RPS6KA1 | |
| SCHEMBL10065438 | 0.78 | RPS6KA3 (0.49) | RPS6KA3NPC1RAB9AAURKAAURKB | |
| SCHEMBL10065437 | 0.78 | RPS6KA3 (0.38) | RPS6KA3NPC1RAB9AAURKAAURKB | |
| SCHEMBL10080851 | 0.77 | MEN1 (0.41) | RPS6KA3NPC1RAB9AAURKAAURKB | |
| SCHEMBL12101685 | 0.77 | BRD4 (0.34) | RPS6KA3BRD4VRK2VRK1JAK2 | |
| SCHEMBL10065444 | 0.77 | BRD4 (0.49) | BRD4 | |
| SCHEMBL10065440 | 0.75 | BRD4 (0.46) | RPS6KA3BRD4VRK2VRK1JAK2 | |
| SCHEMBL21916321 | 0.73 | PLK1 (0.68) | RPS6KA3BRD4CSNK1A1RPS6KA2RPS6KA1 | |
| SCHEMBL861947 | 0.73 | PLK1 (0.68) | RPS6KA3BRD4CSNK1A1RPS6KA2RPS6KA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8193188-B2 | Methods of using pyridodihydropyrazinones | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-05 | — | — | US | disclosed |
| US-8193188-B2 | Methods of using pyridodihydropyrazinones | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-05 | — | — | US | disclosed |
| US-20100029642-A1 | Methods of Using Pyridodihydropyrazinones | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-02-04 | — | — | US | disclosed |
| US-20100029642-A1 | Methods of Using Pyridodihydropyrazinones | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-02-04 | — | — | US | disclosed |
| US-7625899-B2 | Pyridodihydropyraziones, process for their manufacture and use thereof as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |
| US-7625899-B2 | Pyridodihydropyraziones, process for their manufacture and use thereof as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029642-A1 | Methods of Using Pyridodihydropyrazinones | CYP2D6, CYP2B6, C5 | RPS6KA3 217/4885STK4 1895/4885BRD4 1717/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.