Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 17/20 | 0.52 |
| ▸ | BRD4 | O60885 | 13/20 | 0.52 |
| ▸ | PLK3 | Q9H4B4 | 7/20 | 0.47 |
| ▸ | PLK2 | Q9NYY3 | 5/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.47 |
| ▸ | CLK2 | P49760 | 3/20 | 0.47 |
| ▸ | CAMK2G | Q13555 | 3/20 | 0.47 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.47 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.47 |
| ▸ | CSNK1G1 | Q9HCP0 | 3/20 | 0.47 |
| ▸ | CSNK1G3 | Q9Y6M4 | 3/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.47 |
| ▸ | PRKCG | P05129 | 2/20 | 0.47 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.47 |
| ▸ | NEK4 | P51957 | 2/20 | 0.47 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.44 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10065440 | 0.90 | BRD4 (0.46) | PLK1BRD4RPS6KA3BRDTTAF1 | |
| SCHEMBL10065441 | 0.86 | RPS6KA3 (0.44) | PLK1BRD4PLK3PLK2RPS6KA3 | |
| SCHEMBL861947 | 0.85 | PLK1 (0.68) | PLK1BRD4PLK3PLK2PTK2 | |
| SCHEMBL21916321 | 0.85 | PLK1 (0.68) | PLK1BRD4PLK3PLK2PTK2 | |
| SCHEMBL10065439 | 0.81 | PLK1 (0.41) | PLK1BRD4PLK3PLK2PTK2 | |
| SCHEMBL10081358 | 0.81 | MEN1 (0.41) | PLK1BRD4PLK3PLK2PTK2 | |
| SCHEMBL10065446 | 0.79 | BRD4 (0.56) | PLK1BRD4BRDTTAF1 | |
| SCHEMBL21527053 | 0.77 | RPS6KA3 (0.62) | PLK1BRD4PLK3PLK2RPS6KA3 | |
| SCHEMBL862198 | 0.77 | RPS6KA3 (0.62) | PLK1BRD4PLK3PLK2RPS6KA3 | |
| SCHEMBL12323787 | 0.76 | PLK1 (0.78) | PLK1BRD4PLK3PLK2PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1768981-B1 | NOVEL PYRIDODIHYDROPYRAZINONES METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INT (DE) | 2012-09-12 | — | — | EP | disclosed |
| US-8193188-B2 | Methods of using pyridodihydropyrazinones | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-05 | — | — | US | disclosed |
| US-8193188-B2 | Methods of using pyridodihydropyrazinones | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-05 | — | — | US | disclosed |
| US-20100029642-A1 | Methods of Using Pyridodihydropyrazinones | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-02-04 | — | — | US | disclosed |
| US-20100029642-A1 | Methods of Using Pyridodihydropyrazinones | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-02-04 | — | — | US | disclosed |
| US-7625899-B2 | Pyridodihydropyraziones, process for their manufacture and use thereof as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |
| US-7625899-B2 | Pyridodihydropyraziones, process for their manufacture and use thereof as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029642-A1 | Methods of Using Pyridodihydropyrazinones | CYP2D6, CYP2B6, C5 | PLK1 1023/4885BRD4 1717/4885PLK3 128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.