⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL47739 | 0.67 | — | — | |
| SCHEMBL277083 | 0.67 | — | — | |
| SCHEMBL5719204 | 0.67 | — | — | |
| SCHEMBL4162328 | 0.63 | ALDH1A1 (0.36) | — | |
| SCHEMBL18641296 | 0.63 | — | — | |
| SCHEMBL27750855 | 0.63 | — | — | |
| SCHEMBL27952649 | 0.63 | — | — | |
| Hydrochloric Acid SCHEMBL27782124 | 0.63 | — | — | |
| SCHEMBL4119428 | 0.59 | — | — | |
| SCHEMBL3666143 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220009946-A1 | FUSED HETEROCYCLIC BENZODIAZEPINE DERIVATIVES AND USES THEREOF | INTOCELL, INC. (KR) | 2022-01-13 | — | — | US | disclosed |
| WO-2020167566-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF ALCOHOL USE DISORDERS | THE ROCKEFELLER UNIVERSITY (US) | 2020-08-20 | — | — | WO | disclosed |
| US-10711037-B2 | Chemical and biochemical adducts as biomarkers for organophosphate exposure | HUMAN BIOMOLECULAR RESEARCH INSTITUTE (US) | 2020-07-14 | — | — | US | disclosed |
| US-10570088-B2 | Blood brain barrier-penetrating oximes for cholinesterase reactivation | HUMAN BIOMOLECULAR RES FOUNDATION (US) | 2020-02-25 | — | — | US | disclosed |
| US-20170349538-A1 | Blood Brain Barrier-Penetrating Oximes for Cholinesterase Reactivation | Human BioMolecular Research Foundation (US) | 2017-12-07 | — | — | US | disclosed |
| US-9751831-B2 | Blood brain barrier-penetrating oximes for cholistenerases reactivation | HUMAN BIOMOLECULAR RESEARCH INSTITUTE (US) | 2017-09-05 | — | — | US | disclosed |
| US-20170101441-A1 | CHEMICAL AND BIOCHEMICAL ADDUCTS AS BIOMARKERS FOR ORGANOPHOSPHATE EXPOSURE | Human BioMolecular Research Foundation (US) | 2017-04-13 | — | — | US | disclosed |
| US-20170097334-A1 | SCREEN FOR INHIBITORS OF FILOVIRUS AND USES THEREFOR | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-04-06 | — | — | US | disclosed |
| US-9549991-B2 | Chemical and biochemical adducts as biomarkers for organophosphate exposure | HUMAN BIOMOLECULAR RESEARCH INSTITUTE (US) | 2017-01-24 | — | — | US | disclosed |
| EP-2276510-B1 | Chemical and biochemical adducts as biomarkers for organophosphate exposure | HUMAN BIOMOLECULAR RES INST (US) | 2016-07-06 | — | — | EP | disclosed |
| US-20090054312-A1 | SMIPs: Small molecule inhibitors of p27 depletion in cancers and other proliferative diseases | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2009-02-26 | — | — | US | disclosed |
| WO-2008153760-A1 | INHIBITORS OF THAPSIGARGIN-INDUCED CELL DEATH | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2008-12-18 | — | — | WO | disclosed |
| WO-2008118626-A9 | INHIBITORS OF JNK AND METHODS FOR IDENTIFYING INHIBITORS OF JNK | BURNHAM INST MEDICAL RESEARCH (US) | 2008-12-18 | — | — | WO | disclosed |
| US-20080293699-A1 | Inhibitors of thapsigargin-induced cell death | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2008-11-27 | — | — | US | disclosed |
| WO-2008118626-A2 | INHIBITORS OF JNK AND METHODS FOR IDENTIFYING INHIBITORS OF JNK | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2008-10-02 | — | — | WO | disclosed |
| US-20080206287-A1 | Use of cyclosporin A to sensitize resistant cancer cells to death receptor ligands | REED JOHN C | 2008-08-28 | — | — | US | disclosed |
| US-20080166378-A1 | DEATH RECEPTOR SENSITIZING COMPOUNDS AND METHODS OF USE THEREFOR | THE BURNHAM INSTITUTE | 2008-07-10 | — | — | US | disclosed |
| WO-2008070347-A2 | BETULIN-PEPTIDE CONJUGATES | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2008-06-12 | — | — | WO | disclosed |
| WO-2008036244-A1 | USE OF CYCLOSPORIN A TO SENSITIZE RESISTANT CANCER CELLS TO DEATH RECEPTOR LIGANDS | THE BURHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2008-03-27 | — | — | WO | disclosed |
| US-20070203236-A1 | NOVEL ANTAGONISTS OF THE HUMAN FATTY ACID SYNTHASE THIOESTERASE | UNITED STATES GOVERNMENT | 2007-08-30 | — | — | US | disclosed |