Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | CCNC | P24863 | 9/20 | 0.44 |
| ▸ | CDK8 | P49336 | 9/20 | 0.44 |
| ▸ | CDK19 | Q9BWU1 | 9/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1007107 | 0.81 | NPSR1 (0.60) | KDM4EALDH1A1POLBRXFP1NPSR1 | |
| SCHEMBL4401833 | 0.69 | NPSR1 (0.68) | KDM4EALDH1A1POLBRXFP1CCNC | |
| SCHEMBL31564002 | 0.67 | ALDH1A1 (0.64) | KDM4EALDH1A1POLBRXFP1CCNC | |
| SCHEMBL15364318 | 0.66 | KDM4E (0.50) | KDM4EALDH1A1POLBRXFP1CCNC | |
| SCHEMBL7250825 | 0.64 | KDM4E (0.54) | KDM4EALDH1A1POLBRXFP1CCNC | |
| SCHEMBL7250823 | 0.64 | KDM4E (0.54) | KDM4EALDH1A1POLBRXFP1CCNC | |
| SCHEMBL7680675 | 0.63 | ALDH1A1 (0.53) | KDM4EALDH1A1POLBRXFP1CCNC | |
| SCHEMBL6990354 | 0.62 | CCNC (0.64) | KDM4EALDH1A1POLBRXFP1CCNC | |
| SCHEMBL18429106 | 0.62 | CCNC (0.79) | KDM4EALDH1A1POLBRXFP1CCNC | |
| SCHEMBL6986479 | 0.62 | KDM4E (0.52) | KDM4EALDH1A1POLBRXFP1CCNC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110118236-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-05-19 | — | — | US | disclosed |
| EP-2269990-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2011-01-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118236-A1 | HETEROCYCLIC COMPOUND | GRIN1, GRM1, GRIK1 | KDM4E 3157/4885ALDH1A1 614/4885POLB 3571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.