Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.31 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.31 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.31 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.31 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10067713 | 0.81 | CYP11B1 (0.33) | GPR119 | |
| SCHEMBL1103971 | 0.81 | GPR119 (0.44) | GPR119 | |
| SCHEMBL10068055 | 0.80 | HDAC3 (0.36) | GPR119HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL904154 | 0.76 | GPR119 (0.33) | GPR119 | |
| SCHEMBL10068056 | 0.75 | NTRK1 (0.34) | GPR119 | |
| SCHEMBL10067584 | 0.73 | GPR119 (0.41) | GPR119 | |
| SCHEMBL10067427 | 0.73 | GPR119 (0.41) | GPR119 | |
| SCHEMBL904090 | 0.73 | GPR119 (0.41) | GPR119 | |
| SCHEMBL903973 | 0.73 | HDAC3 (0.36) | GPR119HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL10067574 | 0.73 | OGA (0.35) | GPR119HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |