GPR119 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL114213	1.00	20/20
SCHEMBL288614	1.00	20/20
SCHEMBL288892	1.00	20/20
SCHEMBL287689	0.81	20/20
SCHEMBL288589	0.80	20/20
SCHEMBL289195	0.76	20/20
SCHEMBL288618	0.75	20/20
SCHEMBL288058	0.73	20/20
SCHEMBL288167	0.70	20/20
SCHEMBL288948	0.65	20/20
SCHEMBL288318	0.61	20/20
SCHEMBL288366	0.60	20/20
SCHEMBL288373	0.58	20/20
SCHEMBL288503	0.57	20/20
SCHEMBL288936	0.57	20/20
SCHEMBL288249	0.57	20/20
SCHEMBL288620	0.56	20/20
SCHEMBL148647	0.55	20/20
SCHEMBL121348	0.52	20/20
SCHEMBL174827	0.51	20/20

Clinical trials — most relevant to GPR119 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Mazdutide for Adults With Prediabetes: A Randomized, Double-Blind, Placebo-Controlled Trial (DREAM-PRE)	PHASE4	NOT_YET_RECRUITING
Effects of Liraglutide in Young Adults With Type 2 DIAbetes (LYDIA)	PHASE3	COMPLETED
Efficacy and Safety of Alogliptin Plus Metformin in Patients With Type 2 Diabetes	PHASE3	COMPLETED
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus	PHASE3	UNKNOWN
A Dose-response Study Examining the Contribution of GLP-1 Receptor Signaling to Glucagon-stimulated Insulin Secretion	PHASE3	COMPLETED
GPR119 Agonist for Hypoglycemia in Type 1 Diabetes	PHASE2	COMPLETED
Studying the Influence of LEAP2 on Integrated Endocrine Control of Eating During Semaglutide Treatment	PHASE1/PHASE2	RECRUITING
HP-211 Safety and Proof of Concept Dose Ranging Study in Patients With Type 2 Diabetes	PHASE2	RECRUITING
The Role of Endocannabinoids in Insulin Production and Action	PHASE1	COMPLETED
Role of the Gut Sweet Taste Receptor in the Secretion of Satiation Peptides	PHASE1	COMPLETED
Role of the Gut Sweet Taste Receptor in the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
Acute Effect of HP-211 (Axulin) on Blood Glucose and Serum Insulin Responses in Healthy Lean and Overweight Humans	PHASE1	COMPLETED
Sweet Taste Receptors and the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
Diet Oil Induced Stimulation of GLP-1	EARLY_PHASE1	COMPLETED
Dose-response Effect of Pine Nut Oil as a Dual FFA1 and FFA4 Agonist on Glucose Tolerance in Healthy Humans.	nan	COMPLETED
FFAR Agonist on Incretins, Insulin, Lipids and Inflammation	nan	COMPLETED
-Oleoyl Glycerol is a GPR119 Agonist and Signals GLP-1 Release in Humans.	nan	COMPLETED
Effect of Dietary Oils as G-protein-coupled Receptor Agonists on Glucose Tolerance	nan	UNKNOWN
Effect of Glucagon-like Peptide-1 (GLP-1) Receptor Agonist Stimulation on Smoking Consumption in Type 2 Diabetes Patients	nan	ENROLLING_BY_INVITATION
Growth Hormone Signaling in Vivo in Humans	nan	COMPLETED
Hepatic Metabolic Changes in Response to Glucagon Infusion	nan	COMPLETED
Investigating Glucose Metabolism of LEAP2 With Total-body PET/CT	nan	ACTIVE_NOT_RECRUITING
The Importance of Ghrelin for Glucose Metabolism After Sleeve Gastrectomy	nan	COMPLETED
Clinical, Morphometric and Biochemical Effects on Adiposopathy Associated With the Use of GLP-1RA in CKD	nan	RECRUITING
Improving Cardiovascular Disease Diagnosis and Treatment in Kazakhstan Using Metabolic Correction With GLP-1 Drugs	nan	ACTIVE_NOT_RECRUITING
Effects of Obesity and Intensity of Exercise on Ghrelin Levels	nan	COMPLETED
Glucose Response, Excursions And Treatment (GREAT) Study	nan	COMPLETED
Separate and Combined Extrapancreatic Effects of the Incretin Hormones	nan	COMPLETED
Effects of Polyphenols Found in Pomegranate and Olives Food Supplements on Postprandial Blood Glucose in Vivo.	nan	COMPLETED
Effect of Glucagon on Fasting Insulin Secretion and Glucose Metabolism in Subjects Without Type 2 Diabetes	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a GPR119 binder may also engage these)

Protein	Name	Similarity
Q7TQP3	—	1.000	Q7TQP3 →
CNR2	Cannabinoid receptor 2	0.985	landscape →
Q9QZN9	—	0.983	Q9QZN9 →
P56448	—	0.981	P56448 →
P47936	—	0.980	P47936 →
P55167	—	0.979	P55167 →
Q864K5	—	0.979	Q864K5 →
Q0Q460	—	0.979	Q0Q460 →
Q6A155	—	0.979	Q6A155 →
P56447	—	0.978	P56447 →
Q864K7	—	0.978	Q864K7 →
O19037	—	0.977	O19037 →
Q864G2	—	0.977	Q864G2 →
Q864L0	—	0.977	Q864L0 →
Q91178	—	0.977	Q91178 →
Q864K2	—	0.976	Q864K2 →
O77616	—	0.976	O77616 →
Q864K3	—	0.976	Q864K3 →
Q9TUK4	—	0.976	Q9TUK4 →
Q864J0	—	0.976	Q864J0 →
Q01727	—	0.975	Q01727 →
Q864J7	—	0.975	Q864J7 →
Q864G6	—	0.975	Q864G6 →
Q864F9	—	0.975	Q864F9 →
Q864K6	—	0.975	Q864K6 →
P56445	—	0.975	P56445 →
P56442	—	0.974	P56442 →
Q864K8	—	0.974	Q864K8 →
Q864K4	—	0.974	Q864K4 →
Q80SS9	—	0.974	Q80SS9 →