Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS2 | Q07890 | 1/20 | 0.68 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.52 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MPO | P05164 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29405720 | 0.89 | SOS2 (0.68) | SOS2HTR2AMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL2033276 | 0.89 | SOS2 (0.68) | SOS2HTR2AMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL10023253 | 0.89 | SOS2 (0.68) | SOS2HTR2AMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL31369774 | 0.89 | SOS2 (0.68) | SOS2HTR2AMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL2033277 | 0.89 | SOS2 (0.68) | SOS2HTR2AMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL23859779 | 0.85 | SOS2 (0.63) | SOS2HTR2AMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL10849704 | 0.85 | SOS2 (0.63) | SOS2HTR2AMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL19846987 | 0.85 | SOS2 (0.48) | SOS2HTR2AMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL19846988 | 0.85 | HTR2A (0.54) | SOS2HTR2AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL24042700 | 0.81 | SOS2 (0.57) | SOS2HTR2AMAPTSMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012173846-A2 | PEPTIDOMIMETIC MACROCYCLES | AILERON THERAPEUTICS, INC. (US) | 2012-12-20 | — | — | WO | disclosed |
| WO-2012021876-A2 | PEPTIDOMIMETIC MACROCYCLES | AILERON THERAPEUTICS, INC. (US) | 2012-02-16 | — | — | WO | disclosed |
| WO-2012021875-A1 | PEPTIDOMIMETIC MACROCYCLES WITH TRIAZOLE LINKERS | AILERON THERAPEUTICS, INC. (US) | 2012-02-16 | — | — | WO | disclosed |