Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 16/20 | 0.81 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.49 |
| ▸ | ITGA2 | P17301 | 2/20 | 0.49 |
| ▸ | MELK | Q14680 | 1/20 | 0.47 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.47 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.47 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10311384 | 1.00 | ROCK2 (0.81) | ROCK2ITGB3ITGA2MELKPRKCE | |
| SCHEMBL10311381 | 1.00 | ROCK2 (0.81) | ROCK2ITGB3ITGA2MELKPRKCE | |
| SCHEMBL10069854 | 0.95 | ROCK2 (0.78) | ROCK2ITGB3ITGA2MELKPRKCE | |
| SCHEMBL10069856 | 0.89 | ROCK2 (1.00) | ROCK2PKN2 | |
| SCHEMBL10069803 | 0.89 | ROCK2 (1.00) | ROCK2PKN2 | |
| SCHEMBL10069851 | 0.89 | ROCK2 (1.00) | ROCK2PKN2 | |
| SCHEMBL10070957 | 0.88 | ROCK2 (0.89) | ROCK2PKN2 | |
| SCHEMBL10277709 | 0.88 | ROCK2 (0.74) | ROCK2ITGB3ITGA2MELKPRKCE | |
| SCHEMBL10070964 | 0.85 | ROCK2 (0.79) | ROCK2 | |
| SCHEMBL10070389 | 0.85 | ROCK2 (0.79) | ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012006202-A1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-01-12 | — | — | WO | disclosed |