Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.73 |
| ▸ | MEN1 | O00255 | 7/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | F2R | P25116 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 3/20 | 0.66 |
| ▸ | TP53 | P04637 | 2/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.50 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10069964 | 0.85 | SMN1; SMN2 (1.00) | KMT2ASMN1; SMN2MEN1ALDH1A1F2R | |
| SCHEMBL378588 | 0.83 | GAA (0.69) | KMT2ASMN1; SMN2MEN1ALDH1A1F2R | |
| SCHEMBL10069967 | 0.82 | KMT2A (0.85) | KMT2ASMN1; SMN2MEN1ALDH1A1F2R | |
| SCHEMBL10069966 | 0.82 | SMN1; SMN2 (0.77) | KMT2ASMN1; SMN2MEN1ALDH1A1F2R | |
| SCHEMBL874580 | 0.80 | F2R (1.00) | KMT2ASMN1; SMN2ALDH1A1F2RRAB9A | |
| SCHEMBL10069965 | 0.80 | KMT2A (1.00) | KMT2ASMN1; SMN2MEN1ALDH1A1F2R | |
| SCHEMBL10069969 | 0.80 | KMT2A (0.67) | KMT2ASMN1; SMN2MEN1ALDH1A1F2R | |
| SCHEMBL12310041 | 0.79 | KMT2A (1.00) | KMT2ASMN1; SMN2MEN1ALDH1A1RAB9A | |
| SCHEMBL7402722 | 0.79 | PTPN1 (0.73) | KMT2ASMN1; SMN2MEN1ALDH1A1RAB9A | |
| SCHEMBL26835738 | 0.77 | RAB9A (0.72) | KMT2ASMN1; SMN2MEN1ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9422262-B2 | Compounds and methods for treating diseases mediated by protease activated receptors | THE BROAD INSTITUTE, INC. (US) | 2016-08-23 | — | — | US | disclosed |
| US-9422262-B2 | Compounds and methods for treating diseases mediated by protease activated receptors | THE BROAD INSTITUTE, INC. (US) | 2016-08-23 | — | — | US | disclosed |
| WO-2012040636-A2 | COMPOUNDS AND METHODS FOR TREATING DISEASES MEDIATED BY PROTEASE ACTIVATED RECEPTORS | THE BROAD INSTITUTE, INC. (US) | 2012-03-29 | — | — | WO | disclosed |