Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.78 |
| ▸ | NPC1 | O15118 | 7/20 | 0.78 |
| ▸ | RAB9A | P51151 | 7/20 | 0.78 |
| ▸ | IKBKB | O14920 | 5/20 | 0.78 |
| ▸ | CASP3 | P42574 | 2/20 | 0.78 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.78 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.78 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.60 |
| ▸ | MEN1 | O00255 | 7/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5195941 | 0.89 | KDM4E (0.76) | MAPTKDM4ENPC1RAB9AIKBKB | |
| SCHEMBL5370617 | 0.89 | MAPT (0.76) | MAPTKDM4ENPC1RAB9AIKBKB | |
| SCHEMBL1531346 | 0.88 | MAPT (1.00) | MAPTKDM4ENPC1RAB9AIKBKB | |
| SCHEMBL1724239 | 0.88 | IKBKB (1.00) | MAPTKDM4ENPC1RAB9AIKBKB | |
| SCHEMBL431794 | 0.88 | MAPT (0.74) | MAPTKDM4ENPC1RAB9AIKBKB | |
| Hydrochloric Acid SCHEMBL8864118 | 0.86 | MAPT (0.72) | MAPTKDM4ENPC1RAB9AIKBKB | |
| SCHEMBL14975506 | 0.85 | KDM4E (0.71) | MAPTKDM4ENPC1RAB9AIKBKB | |
| SCHEMBL5192819 | 0.85 | MAPT (0.71) | MAPTKDM4ENPC1RAB9AIKBKB | |
| SCHEMBL613186 | 0.85 | MAPT (0.70) | MAPTKDM4ENPC1RAB9AIKBKB | |
| SCHEMBL23657912 | 0.83 | MAPT (0.67) | MAPTKDM4ENPC1RAB9AIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |