Sugi Predict

Sugi Predict / Compounds / SCHEMBL1724239

SCHEMBL1724239

SCHEMBL1724239

COC(=O)c1sc(-c2ccc(F)cc2)cc1N

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ IKBKB O14920 6/20 1.00
▸ MAPT P10636 11/20 0.74
▸ KDM4E B2RXH2 9/20 0.74
▸ NPC1 O15118 6/20 0.74
▸ RAB9A P51151 6/20 0.74
▸ CASP3 P42574 2/20 0.74
▸ SENP8 Q96LD8 2/20 0.74
▸ SENP7 Q9BQF6 2/20 0.74
▸ SENP6 Q9GZR1 2/20 0.74
▸ SMN1; SMN2 Q16637 3/20 0.73
▸ CYP1A2 P05177 2/20 0.68
▸ CYP2C9 P11712 2/20 0.68
▸ CYP2C19 P33261 2/20 0.68
▸ CHUK O15111 1/20 0.68
▸ CYP3A4 P08684 1/20 0.68
▸ TUBB4A P04350 1/20 0.62
▸ TUBB P07437 1/20 0.62
▸ TUBA3C P0DPH7 1/20 0.62
▸ TUBA1B P68363 1/20 0.62
▸ TUBA4A P68366 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10070140 0.88 MAPT (0.78) IKBKBMAPTKDM4ENPC1RAB9A
SCHEMBL1405912 0.87 IKBKB (0.78) IKBKBMAPTKDM4ENPC1RAB9A
SCHEMBL5195941 0.87 KDM4E (0.76) IKBKBMAPTKDM4ENPC1RAB9A
SCHEMBL5370617 0.87 MAPT (0.76) IKBKBMAPTKDM4ENPC1RAB9A
SCHEMBL5197381 0.86 IKBKB (0.75) IKBKBMAPTKDM4ENPC1RAB9A
SCHEMBL1531346 0.85 MAPT (1.00) IKBKBMAPTKDM4ENPC1RAB9A
SCHEMBL431794 0.85 MAPT (0.74) IKBKBMAPTKDM4ENPC1RAB9A
Hydrochloric Acid SCHEMBL8864118 0.84 MAPT (0.72) IKBKBMAPTKDM4ENPC1RAB9A
SCHEMBL5195621 0.83 IKBKB (0.71) IKBKBMAPTKDM4ENPC1RAB9A
SCHEMBL14975506 0.83 KDM4E (0.71) IKBKBMAPTKDM4ENPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230399322-A1 EIF4E INHIBITORS AND USES THEREOF PIC Therapeutics, Inc. 2023-12-14 — — US disclosed
US-20230399322-A1 EIF4E INHIBITORS AND USES THEREOF PIC Therapeutics, Inc. 2023-12-14 — — US disclosed
US-11753403-B2 EIF4E inhibitors and uses thereof PIC Therapeutics, Inc. (US) 2023-09-12 — — US disclosed
US-11753403-B2 EIF4E inhibitors and uses thereof PIC Therapeutics, Inc. (US) 2023-09-12 — — US disclosed
WO-2021178488-A1 EIF4E INHIBITORS AND USES THEREOF PIC Therapeutics, Inc. (US) 2021-09-10 — — WO disclosed
EP-2403860-B1 PHOSPHOTHIOPHENE AND PHOSPHOTHIAZOLE AS HCV POLYMERASE INHIBITORS IDENIX PHARMACEUTICALS INC (US) 2015-11-04 — — EP disclosed
US-8829030-B2 Compounds and methods for the treatment or prevention of Flavivirus infections VERTEX PHARMACEUTICALS (CANADA) INCORPORATED (CA) 2014-09-09 — — US disclosed
US-8829030-B2 Compounds and methods for the treatment or prevention of Flavivirus infections VERTEX PHARMACEUTICALS (CANADA) INCORPORATED (CA) 2014-09-09 — — US disclosed
US-8829030-B2 Compounds and methods for the treatment or prevention of Flavivirus infections VERTEX PHARMACEUTICALS (CANADA) INCORPORATED (CA) 2014-09-09 — — US disclosed
US-20130096106-A1 COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS VERTEX PHARMACEUTICALS (CANADA) INCORPORATED (CA) 2013-04-18 — — US disclosed
WO-2004052885-A1 COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS VIROCHEM PHARMA INC. (CA) 2004-06-24 — — WO disclosed
WO-2003029242-A1 NF-λB INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2003-04-10 — — WO disclosed
WO-2003028731-A1 CHK1 KINASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2003-04-10 — — WO disclosed
US-20020165398-A1 Modulators of protein tyrosine phosphatases (PTPases) JEPPESEN LONE (DK) 2002-11-07 — — US disclosed
US-20020002199-A1 MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) NOVO NORDISK A/S (DK) 2002-01-03 — — US disclosed
CN-1300279-A Modulators of protein tyrosine phosphatases NOVO NORDISK AS (DK) 2001-06-20 — — CN disclosed
EP-1080068-A1 MODULATORS OF PROTEIN TYROSINE PHOSPHATASES Novo Nordisk A/S (DK) 2001-03-07 — — EP disclosed
EP-1062204-A1 MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) NOVO NORDISK A/S (DK) 2000-12-27 — — EP disclosed
WO-1999046237-A1 MODULATORS OF PROTEIN TYROSINE PHOSPHATASES NOVO NORDISK A/S (DK) 1999-09-16 — — WO disclosed
WO-1999046244-A1 MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) NOVO NORDISK A/S (DK) 1999-09-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020165398-A1 Modulators of protein tyrosine phosphatases (PTPases) PTPRCAP, PTPRS, PTPRO IKBKB 1687/4885MAPT 540/4885KDM4E 2277/4885
US-20230399322-A1 EIF4E INHIBITORS AND USES THEREOF EIF4E, EIF4EBP1, EIF4A1 IKBKB 1081/4885MAPT 2231/4885KDM4E 710/4885
US-11753403-B2 EIF4E inhibitors and uses thereof EIF4E, EIF4EBP1, EIF4A1 IKBKB 1081/4885MAPT 2231/4885KDM4E 710/4885
US-20130096106-A1 COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS ZC3HAV1, ZYX, ZFX IKBKB 994/4885MAPT 1641/4885KDM4E 1505/4885
US-20020002199-A1 MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) PTPRCAP, PTPRS, PTPRA IKBKB 1694/4885MAPT 475/4885KDM4E 2352/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.